Clotrimazole Impurity 22 CAS 59154-29-9
| CAS No. | 59154-29-9 |
| Molecular Formula | C19H14Cl2 |
| Molecular Weight | 313.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Clotrimazole Impurity 22 (CAS 59154-29-9, C19H14Cl2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C19H14Cl2, Clotrimazole Impurity 22 contains chlorine substitution, a polycyclic aromatic system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 313.22 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H14Cl2 |
| Molecular Weight | 313.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
Related Clotrimazole Standards
- Clotrimazole Impurity 20 (CAS 27023-37-6)
- Clotrimazole EP Impurity C (CAS 42074-68-0)
- Clotrimazole EP Impurity F (CAS 15469-97-3)
- Clotrimazole Impurity 17 (CAS 717109-42-7)
- Clotrimazole Impurity 8 (CAS CATO-C4X-15698)
- Clotrimazole Impurity 18 (CAS 717109-43-8)
- Clotrimazole Impurity 9 (CAS 23593-68-2)
- Clotrimazole Impurity 29 (CAS 103855-36-3)
Recommended Standards
- Bifonazole Impurity 15 (CAS CATO-C4X-156015)
- Losartan Impurity 47 (CAS CATO-C4X-168347)
- rel-(1R,3S)-Ethyl 3-((Z)-2-chloro-2-(4-chlorophenyl)vinyl)-2,2-dimethylcyclopropanecarboxylate (CAS 78479-01-3)
- Diclocymet (CAS 139920-32-4)
- Terazosin EP Impurity D HCl (CAS 84050-21-5)
- Clotrimazole Impurity 13 (CAS 108-41-8)
- Ranitidine Impurity 21 (CAS 112233-25-7)
- Ruxolitinib Impurity 109 (CAS CATO-C4X-2058109)
- Hydroxychloroquine Impurity 12 (CAS CATO-C4X-183512)
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