Clotrimazole Impurity 18 CAS 717109-43-8
| CAS No. | 717109-43-8 |
| Molecular Formula | C21H19ClO |
| Molecular Weight | 322.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Clotrimazole Impurity 18 (CAS 717109-43-8, C21H19ClO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Clotrimazole Impurity 18 (C21H19ClO) contains a steroid core, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 322.83 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H19ClO |
| Molecular Weight | 322.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
Related Clotrimazole Standards
- Clotrimazole Impurity 9 (CAS 23593-68-2)
- Clotrimazole Impurity 29 (CAS 103855-36-3)
- Clotrimazole Impurity 20 (CAS 27023-37-6)
- Clotrimazole Impurity 22 (CAS 59154-29-9)
- Clotrimazole EP Impurity C (CAS 42074-68-0)
- Clotrimazole EP Impurity F (CAS 15469-97-3)
- Clotrimazole Impurity 17 (CAS 717109-42-7)
- Clotrimazole Impurity 8 (CAS CATO-C4X-15698)
Recommended Standards
- tert-Butyl 5-chlorospiro[indoline-3,4'-piperidine]-1'-carboxylate (CAS 637362-21-1)
- (S)-7-chloro-5-((1-phenylethyl)thio)thiazolo[4,5-d]pyrimidin-2-amine (CAS 911820-08-1)
- N-(3-chlorophenyl)-2-methyl-1-oxa-4-azaspiro[4.6]Undecane-4-carboxamide (CAS 633299-25-9)
- 3-((4-Chlorobenzyl)thio)-5-(thiophen-2-yl)-4H-1,2,4-triazol-4-amine (CAS 477872-66-5)
- Cefetamet Impurity 2 (CAS CATO-C4X-12872)
- Nicorandil Impurity 57 (CAS 342018-76-2)
- Racecadotril EP Impurity H (CAS 141437-88-9)
- 4-Chloro-1-(oxetan-3-yl)-1h-pyrazol-3-amine (CAS 2137547-75-0)
- (E)-Doxepin Hydrochloride (CAS 4698-39-9)
- 4-(tert-Butyl)-N-(2-fluorobenzyl)aniline (CAS 1042513-60-9)
- Methyl 2-(Bromomethyl)acrylate (CAS 4224-69-5)
- 4-Methoxy-N-(1-(thiazol-2-yl)ethyl)butan-1-amine (CAS 1468532-16-2)
- 5-Bromo-3-methyl-2-(methylthio)pyridine (CAS 1289270-74-1)
- Semaglutide Impurity 124 (CAS CATO-C4X-2226124)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com