Tacrolimus EP Impurity F CAS 1393890-33-9
| CAS No. | 1393890-33-9 |
| Molecular Formula | C44H69NO12 |
| Molecular Weight | 804.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Tacrolimus EP Impurity F (CAS 1393890-33-9) is a certified pharmaceutical impurity reference standard with the molecular formula C44H69NO12 and a molecular weight of 804.02 g/mol.
Structurally, Tacrolimus EP Impurity F (C44H69NO12) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 804.02 g/mol, it falls into the high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Tacrolimus EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C44H69NO12 |
| Molecular Weight | 804.02 g/mol |
| Purity | >80% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 1 |
Related Tacrolimus Standards
- Tacrolimus (CAS 104987-11-3)
- Tacrolimus Impurity 15 (CAS CATO-C4X-130015)
- Tacrolimus Impurity 17 (CAS CATO-C4X-130017)
- Tacrolimus EP Impurity G (CAS 144490-63-1)
- Tacrolimus Impurity 36 (CAS 131944-48-4)
- Tacrolimus Impurity 37 (CAS CATO-C4X-130037)
- Tacrolimus Impurity 38 (CAS CATO-C4X-130038)
- Tacrolimus Impurity 43 (CAS CATO-C4X-130043)
Recommended Standards
- (E/Z)-FK-506 26,28-Allylic Ester Rearrangement Impurity (CAS CATO-C4X-130012)
- [Lys5,MeLeu9,Nle10]-Neurokinin A (4-10) Fragment (CAS 137565-28-7)
- Pancreatic Polypeptide (31-36), amide, human (CAS 74012-13-8)
- Tacrolimus Impurity 47 (CAS CATO-C4X-130047)
- Gadoxetate Impurity 17 (CAS CATO-C4X-261817)
- Esomeprazole Impurity 31 (CAS 1114596-75-6)
- Calcitriol Impurity 31 (CAS 96862-25-8)
- N-(4-bromo-3-methyl-2-nitrophenyl)acetamide (CAS 914223-24-8)
- (2S,3S)-2-Amino-3-(methylthio)butanoic acid (CAS 1330779-43-5)
- (R)-4-benzyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole (CAS 2757082-42-9)
- 2,2'-(((1,1,3,3-Tetramethyldisiloxane-1,3-diyl)bis(propane-3,1-diyl))bis(oxy))diethanol (CAS 441307-02-4)
- (R)-2,2',3,3'-Tetrahydro-6,6'-bis[4-(trifluoromethyl)phenyl]-1,1'-spirobi[1H-indene]-7,7'-diol (CAS 1435948-34-7)
- 4-(2-(2-Oxobenzo[d]oxazol-3(2H)-yl)ethoxy)benzaldehyde (CAS 142649-91-0)
- PACAP-Related Peptide (PRP), rat (CAS 132769-35-8)
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