Thiamphenicol Impurity 3 HCl CAS 1071703-93-9
| CAS No. | 1071703-93-9 |
| Molecular Formula | C14H18Cl2N2O6S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 449.72 g/mol gives Thiamphenicol Impurity 3 HCl distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Thiamphenicol Impurity 3 HCl (CAS 1071703-93-9, C14H18Cl2N2O6SHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Thiamphenicol Impurity 3 HCl (C14H18Cl2N2O6SHCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 449.72 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Thiamphenicol Impurity 3 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H18Cl2N2O6S HCl |
| Molecular Weight | 449.72 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Thiamphenicol Standards
- ent-Thiamphenicol-d3 (CAS 1217723-41-5)
- Thiamphenicol Impurity 9 (CAS 126429-09-2)
- Thiamphenicol Impurity 10 (CAS 126813-11-4)
- Thiamphenicol (CAS 15318-45-3)
- Thiamphenicol Impurity 2 (CAS 19934-71-5)
- Thiamphenicol Impurity 6 (CAS 21079-44-7)
- Thiamphenicol Impurity 8 (CAS 2611-61-2)
- Thiamphenicol Impurity 4 (CAS 27348-52-3)
Recommended Standards
- Mycophenolic Acid Impurity 13 Disodium Salt (CAS CATO-C4X-212213)
- Formoterol impurity 133 (CAS CATO-C4X-1525133)
- Amoxicillin Impurity 17 (CAS 1313237-94-3)
- 2-(Difluoromethyl)-5-fluoro-3-methylpyridine-6-sulfonamide (CAS 1805529-38-7)
- 3-Amino-3-(2-chlorophenyl)propanoic acid (CAS 68208-20-8)
- 4,5,6,7-Tetrahydro-1,2-benzisoxazol-4-amine (CAS 927803-62-1)
- 2',5'-Dimethyl-[1,1'-biphenyl]-2-ol (CAS 52220-74-3)
- 1-(3-(1H-imidazol-1-yl)propyl)-4-benzoyl-5-(4-fluorophenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one (CAS 350678-63-6)
- 3,5-Difluoro-4-nitrobenzenesulfonamide (CAS 1804516-06-0)
- Semaglutide Impurity 82 (CAS CATO-C4X-222682)
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