Thiamphenicol Impurity 8 CAS 2611-61-2
| CAS No. | 2611-61-2 |
| Molecular Formula | C14H18Cl2N2O6S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Thiamphenicol Impurity 8 (CAS 2611-61-2) is a certified pharmaceutical impurity reference standard with the molecular formula C14H18Cl2N2O6SHCl and a molecular weight of 449.72 g/mol.
Thiamphenicol Impurity 8 (C14H18Cl2N2O6SHCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C14H18Cl2N2O6S HCl |
| Molecular Weight | 449.72 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Thiamphenicol Standards
- Thiamphenicol Impurity 3 HCl (CAS 1071703-93-9)
- ent-Thiamphenicol-d3 (CAS 1217723-41-5)
- Thiamphenicol Impurity 9 (CAS 126429-09-2)
- Thiamphenicol Impurity 10 (CAS 126813-11-4)
- Thiamphenicol (CAS 15318-45-3)
- Thiamphenicol Impurity 2 (CAS 19934-71-5)
- Thiamphenicol Impurity 6 (CAS 21079-44-7)
- Thiamphenicol Impurity 4 (CAS 27348-52-3)
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