Nebivolol Impurity 65 CAS CATO-C4X-196865
| CAS No. | CATO-C4X-196865 |
| Molecular Formula | C13H15FO3S |
| Molecular Weight | 270.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Nebivolol Impurity 65 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Nebivolol Impurity 65 (CAS CATO-C4X-196865) is a certified pharmaceutical impurity reference standard with the molecular formula C13H15FO3S and a molecular weight of 270.32 g/mol.
Owing to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Nebivolol Impurity 65 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 270.32 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H15FO3S |
| Molecular Weight | 270.32 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 64 (CAS CATO-C4X-196864)
- Nebivolol Impurity 69 (CAS CATO-C4X-196869)
- Nebivolol Impurity 49 (CAS 797054-16-1)
- Nebivolol Impurity 54 (CAS CATO-C4X-196854)
- Nebivolol Impurity 55 (CAS CATO-C4X-196855)
- Nebivolol Impurity 67 (CAS CATO-C4X-196867)
- Nebivolol Impurity 70 (CAS CATO-C4X-196870)
- Nebivolol Impurity 75 (CAS CATO-C4X-196875)
Recommended Standards
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- LCZ-696 Impurity 56 (CAS CATO-C4X-169656)
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- 2-Acetamido-3-(3-fluoro-4-hydroxyphenyl)propanoicacid (CAS 219858-64-7)
- Characteristic MSH-Tetrapeptide (CAS 4289-02-5)
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