Afoxolaner Impurity 1 CAS 1125812-54-5
| CAS No. | 1125812-54-5 |
| Molecular Formula | C17H15F3N2O3 |
| Molecular Weight | 352.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C17H15F3N2O3, Afoxolaner Impurity 1 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 352.31 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Afoxolaner Impurity 1 (CAS 1125812-54-5), a pharmacopoeial impurity reference standard (molecular formula C17H15F3N2O3, MW 352.31 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Afoxolaner Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H15F3N2O3 |
| Molecular Weight | 352.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Afoxolaner Standards
- Afoxolaner Impurity 12 (CAS CATO-C4X-313712)
- Afoxolaner impurity 3 (CAS CATO-C4X-31373)
- Afoxolaner impurity 11 (CAS CATO-C4X-31381)
- Afoxolaner Impurity 33 (CAS CATO-C4X-313733)
- Afoxolaner Impurity 10 (CAS CATO-C4X-313710)
- Afoxolaner Impurity 16 (CAS 1190862-76-0)
- Afoxolaner impurity 6 (CAS CATO-C4X-31376)
- Afoxolaner Impurity 11 (CAS CATO-C4X-313711)
Recommended Standards
- Methyl 5-oxo-6-((2-(trifluoromethyl)phenyl)amino)-1,2,3,5-tetrahydroindolizine-8-carboxylate (CAS 612065-22-2)
- 5-{3-[(3-fluorophenyl)methyl]-1,2,4-oxadiazol-5-yl}-3-(4-methoxyphenyl)-1,2,4-oxadiazole (CAS 1775330-71-6)
- Ethyl 2-(3-{[3-(trifluoromethyl)anilino]carbonyl}-2-pyridinyl)acetate (CAS 338392-12-4)
- (Benzo[d][1,3]dioxol-5-yl(hydroxy)methyl)diphenylphosphine oxide (CAS 5255-64-1)
- Milbemycin Impurity 8 (CAS CATO-C4X-16988)
- Raltitrexed Impurity 32 (CAS CATO-C4X-138632)
- Mesalazine Impurity 42 (CAS 104786-99-4)
- Praseodymium(III) Chloride Heptahydrate (CAS 10025-90-8)
- 3-Cyclopropoxy-2-isopropoxyisonicotinic acid (CAS 1243287-71-9)
- 1-methyl-5-nitro-1H-indazole-3-carboxylic acid (CAS 1363382-25-5)
- (R)-5-Bromo-6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (CAS 2766799-88-4)
- 3-bromo-4-(trifluoromethyl)thiophene (CAS 1803583-11-0)
- 2-Bromo-N-(3-fluorophenyl)acetamide (CAS 73392-04-8)
- Tirzepatide Impurity 37 (CAS CATO-C4X-324037)
Why CATO?
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