Afoxolaner impurity 6 CAS CATO-C4X-31376
| CAS No. | CATO-C4X-31376 |
| Molecular Formula | C22H11ClF6O3 |
| Molecular Weight | 472.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Afoxolaner impurity 6 (CAS CATO-C4X-31376, C22H11ClF6O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Afoxolaner impurity 6 (C22H11ClF6O3) is characterized by a steroid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Afoxolaner impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H11ClF6O3 |
| Molecular Weight | 472.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Afoxolaner Standards
- Afoxolaner Impurity 16 (CAS 1190862-76-0)
- Afoxolaner Impurity 18 (CAS CATO-C4X-313718)
- Afoxolaner Impurity 28 (CAS 1308362-48-2)
- Afoxolaner impurity 7 (CAS CATO-C4X-31377)
- Afoxolaner Impurity 13 (CAS 1125727-10-7)
- Afoxolaner Impurity 23 (CAS CATO-C4X-313723)
- Afoxolaner Impurity 20 (CAS 1125812-60-3)
- Afoxolaner Impurity 15 (CAS CATO-C4X-313715)
Recommended Standards
- 2-(9,9-Dioctyl-9H-fluoren-2-yl)thiophene (CAS 302554-76-3)
- DL-alpha-Tocopherylacetate (CAS 52225-20-4)
- 3-(3-(4-Nitrobenzyl)ureido)benzene-1-sulfonyl fluoride (CAS 21315-98-0)
- All-Rac-Α-Tocopheryl Acetate EP Impurity A (CAS CATO-C4X-177917)
- Bifendate impurity 10 (CAS CATO-C4X-255510)
- Etomidate Impurity N3 (CAS 31502-34-8)
- Afatinib Impurity 29 (CAS 1456696-14-2)
- 1-(3-Nitrophenyl)-2-propyn-1-ol (CAS 83494-25-1)
- 2'-(Trifluoromethyl)-[1,1'-biphenyl]-2-amine hydrochloride (CAS 1208620-12-5)
- 4-(1-Naphthylvinyl)pyridine (CAS 16375-56-7)
- Ethoate-methyl (CAS 116-01-8)
- 2-(4-(Furan-2-carbonyl)piperazin-1-yl)-2-oxoethyl 2-(furan-2-yl)quinoline-4-carboxylate (CAS 485362-61-6)
- 2-(2-Bromo-5-chlorophenoxy)acetic acid (CAS 1785255-91-5)
- Tirzepatide Impurity 33 (CAS CATO-C4X-324033)
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