Afoxolaner Impurity 16 CAS 1190862-76-0
| CAS No. | 1190862-76-0 |
| Molecular Formula | C22H11ClF6O3 |
| Molecular Weight | 472.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Afoxolaner Impurity 16 is closely related to a steroid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Afoxolaner Impurity 16 (CAS 1190862-76-0, C22H11ClF6O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Afoxolaner Impurity 16 (C22H11ClF6O3) is characterized by a steroid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Afoxolaner Impurity 16 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H11ClF6O3 |
| Molecular Weight | 472.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
Related Afoxolaner Standards
- Afoxolaner impurity 6 (CAS CATO-C4X-31376)
- Afoxolaner Impurity 18 (CAS CATO-C4X-313718)
- Afoxolaner Impurity 28 (CAS 1308362-48-2)
- Afoxolaner impurity 7 (CAS CATO-C4X-31377)
- Afoxolaner Impurity 13 (CAS 1125727-10-7)
- Afoxolaner Impurity 23 (CAS CATO-C4X-313723)
- Afoxolaner Impurity 20 (CAS 1125812-60-3)
- Afoxolaner Impurity 15 (CAS CATO-C4X-313715)
Recommended Standards
- DL-alpha-Tocopherylacetate (CAS 52225-20-4)
- All-Rac-Α-Tocopheryl Acetate EP Impurity A (CAS CATO-C4X-177917)
- 2-(9,9-Dioctyl-9H-fluoren-2-yl)thiophene (CAS 302554-76-3)
- All-Rac-Α-Tocopheryl Acetate EP Impurity B (CAS CATO-C4X-177916)
- Allopurinol EP Impurity A Hemisulfate (CAS 27511-79-1)
- Peramivir Impurity 34 (CAS CATO-C4X-183334)
- Eldecalcitol Impurity 7 (CAS CATO-C4X-21407)
- [5-(piperidine-1-sulfonyl)thiophen-2-yl]methanamine hydrochloride (CAS 1049741-22-1)
- 3,5-Difluoro-4-nitroacetophenone (CAS 1804515-90-9)
- 5-Aminobenzene-1,3-dicarbonitrile (CAS 57369-97-8)
- p-Aminoethylbenzaldehyde hcl (CAS 64353-37-3)
- N'-(4-Bromobenzoyl)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbohydrazide (CAS 613659-08-8)
- (4-(Pyrazin-2-yl)thiophen-2-yl)boronic acid (CAS 2225170-48-7)
- Semaglutide impurity 215 (CAS CATO-C4X-2226215)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com