Letrozole Impurity N2 CAS 84545-14-2
| CAS No. | 84545-14-2 |
| Molecular Formula | C8H8ClNO |
| Molecular Weight | 169.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Letrozole Impurity N2.
As a process- or degradation-related impurity, Letrozole Impurity N2 (CAS 84545-14-2, C8H8ClNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Letrozole Impurity N2 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 169.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8ClNO |
| Molecular Weight | 169.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Letrozole Standards
- Letrozole Impurity 17 (CAS 112809-27-5)
- Letrozole Impurity 22 (CAS 876728-37-9)
- Letrozole Impurity 23 (CAS 876316-41-5)
- Letrozole Impurity 4 (CAS 112809-25-3)
- Letrozole Impurity 15 (CAS 74231-65-5)
- Letrozole Impurity 29 (CAS 612-13-5)
- Letrozole Impurity 30 (CAS 64407-07-4)
- Letrozole Impurity 38 (CAS 874-86-2)
Recommended Standards
- N-Methyl-N-phenylcarbamoyl chloride (CAS 4285-42-1)
- 2-Chloro-4-mercaptobenzonitrile (CAS 110888-20-5)
- N-Formyl-4-Chloro-2-Toluidine (CAS 21787-81-5)
- 1-((Chloromethyl)sulfonyl)azetidine (CAS 1343317-78-1)
- Blonanserin Impurity 32 (CAS 132810-83-4)
- Bilastine Impurity 21 (CAS 953071-73-3)
- Empagliflozin impurity 252 (CAS CATO-C4X-1065252)
- 2-Methoxy-N-(3-((n-methylacetamido)methyl)phenyl)acetamide (CAS 1181553-43-4)
- 4-(4-Cyclohexyl-5-mercapto-4H-1,2,4-triazol-3-yl)phenol (CAS 26028-87-5)
- 4-Chloro-5-fluoropyridin-2-amine (CAS 1393562-83-8)
- Ro 51 (CAS 1050670-85-3)
- 1-(2-Amino-2-oxoethyl)-1H-indole-6-carboxylic acid (CAS 885266-80-8)
- Lincomycin EP Impurity C (CAS 14600-41-0)
- Neuropeptide K (human, porcine, rat) trifluoroacetate salt (CAS 96827-05-3)
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