Bortezomib Impurity 1 CAS 289472-80-6
| CAS No. | 289472-80-6 |
| Molecular Formula | C14H14N4O2 |
| Molecular Weight | 270.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Bortezomib Impurity 1 (CAS 289472-80-6) is a certified pharmaceutical impurity reference standard with the molecular formula C14H14N4O2 and a molecular weight of 270.29 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Bortezomib Impurity 1 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 270.29 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Bortezomib Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H14N4O2 |
| Molecular Weight | 270.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 4 |
Related Bortezomib Standards
- Bortezomib Impurity 36 (CAS CATO-C4X-107236)
- Bortezomib Impurity 61 (CAS CATO-C4X-107261)
- Bortezomib Impurity 2 (CAS 114457-94-2)
- Bortezomib Impurity 31 (CAS 1608986-16-8)
- Bortezomib Impurity 80 (CAS 179324-86-8)
- Bortezomib Impurity 49 (CAS 948294-96-0)
- Bortezomib Impurity 40 (CAS 87304-47-0)
- Bortezomib Impurity N46 (CAS 85167-14-2)
Recommended Standards
- Edaravone impurity 40 (CAS CATO-C4X-106240)
- Regorafenib Impurity 31 (CAS CATO-C4X-104731)
- CAS 2483735-57-3 (CAS 2483735-57-3)
- Acotiamide Impurity 30 (CAS CATO-C4X-111430)
- Revefenacin Impurity 45 (CAS CATO-C4X-203145)
- Pilocarpine Hydrochloride EP Impurity C (CAS 34350-99-7)
- Reserpine Impurity 5 (CAS 2901-66-8)
- 4,7-Dibromo-1-ethyl-1H-benzo[d]imidazole (CAS 2365306-39-2)
- N-methyl-1-(5-methyl-6-(piperidin-1-yl)pyridin-3-yl)methanamine (CAS 1355225-07-8)
- 3-(4-Nitro-3-(2,2,2-trifluoroethoxy)-1H-pyrazol-1-yl)propan-1-amine (CAS 1855938-91-8)
- 3-Tert-butyl-1-phenyl-1h-pyrazole-4-carboxylic acid (CAS 1152933-21-5)
- 4-Butoxy-3-(trifluoromethyl)aniline hydrochloride (CAS 1185295-63-9)
- Dipropylcyclopropenone (CAS 698-93-1)
- Acetyl Tripeptide-1 (CAS 350595-76-5)
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