Guaifenesin EP Impurity B-D4 CAS 114609-65-3
| CAS No. | 114609-65-3 |
| Molecular Formula | - |
| Molecular Weight | 202.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Guaifenesin EP Impurity B-D4 (CAS 114609-65-3) is a certified pharmaceutical impurity reference standard with the molecular formula C10H10D4O4 and a molecular weight of 202.24 g/mol.
Structurally, Guaifenesin EP Impurity B-D4 (C10H10D4O4) contains deuterium isotope labeling, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 202.24 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Guaifenesin EP Impurity B-D4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H10D4O4 |
| Molecular Weight | 202.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
Related Guaifenesin Standards
- Guaifenesin-d3 (CAS 1189924-85-3)
- Guaifenesin Impurity 1 (CAS 61248-75-7)
- Guaifenesin EP Impurity B (CAS 14007-09-1)
- Guaifenesin-Glyceryl-<SUP>13</SUP>C<SUB>3</SUB> (CAS 1173019-31-2)
- Guaifenesin Metabolite (Glyceryl Guaiacolate Metabolite) (CAS 13057-65-3)
- Guaifenesin Impurity 5 (CAS 2049-21-0)
- Guaifenesin Impurity 7 (CAS 120-80-9)
- Guaifenesin EP Impurity D (CAS 16929-60-5)
Recommended Standards
- (Z)-2-Hydrazono-2,3-dihydrothiazolo[4,5-b]pyrazine (CAS 107512-51-6)
- 4-(1H-Pyrazol-4-yl)thieno[2,3-d]pyrimidine (CAS 1185700-69-9)
- (2Z)-2-Amino-3-[(E)-[(thiophen-3-yl)methylidene]amino]but-2-enedinitrile (CAS 1024825-62-4)
- ((1s,3R,5S,7s)-4,4-Difluoroadamantan-1-yl)methanol (CAS 1283719-51-6)
- Cilastatin EP Impurity B (Mixture Of Diastereomers) (CAS CATO-C4X-19602)
- Dolutegravir Impurity 19 (CAS 1916490-96-4)
- Gefitinib Impurity 53 (CAS CATO-C4X-111753)
- Decamethonium (iodide) (CAS 1420-40-2)
- 2-(4-Isopropylphenyl)-1H-indole-3-carbaldehyde (CAS 590390-96-8)
- 1,9-Dicyanononane (CAS 71172-36-6)
- (1S,2S,5R)-2-isopropyl-5-methylcyclohexane-1-carbonitrile (CAS 180978-26-1)
- 2-Bromo-3,6-difluorobenzaldehyde, 97% (CAS 934987-26-5)
- 1-(5-(4-Bromophenyl)isoxazol-3-yl)cyclobutanecarboxylic acid (CAS 1352535-22-8)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
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