Guaifenesin EP Impurity B CAS 14007-09-1
| CAS No. | 14007-09-1 |
| Molecular Formula | C10H14O4 |
| Molecular Weight | 198.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Guaifenesin EP Impurity B (C10H14O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Guaifenesin EP Impurity B (CAS 14007-09-1, C10H14O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H14O4 |
| Molecular Weight | 198.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
Related Guaifenesin Standards
- Guaifenesin Impurity 1 (CAS 61248-75-7)
- Guaifenesin-d3 (CAS 1189924-85-3)
- Guaifenesin EP Impurity B-D4 (CAS 114609-65-3)
- Guaifenesin-Glyceryl-<SUP>13</SUP>C<SUB>3</SUB> (CAS 1173019-31-2)
- Guaifenesin Metabolite (Glyceryl Guaiacolate Metabolite) (CAS 13057-65-3)
- Guaifenesin Impurity 5 (CAS 2049-21-0)
- Guaifenesin Impurity 7 (CAS 120-80-9)
- Guaifenesin EP Impurity D (CAS 16929-60-5)
Recommended Standards
- Nitroso Perindopril EP impurity A (CAS CATO-C4X-125245)
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- Mesalazine Impurity 27 (CAS 2362-57-4)
- Tenofovir disoproxil Impurity 78 (CAS CATO-C4X-107678)
- Terbutaline Impurity 15 (CAS 3886-19-9)
- Ticagrelor impurity 25 (CAS CATO-C4X-109325)
- 3-(4-Fluorophenoxy)phenylboronic acid (CAS 283173-82-0)
- Boc-Histidinol(Tos) (CAS 1169760-85-3)
- 5-(2,6-Dichlorophenyl)furan-2-carbaldehyde (CAS 94078-34-9)
- Methyl 2-(2-allyl-3-oxocyclopentyl)acetate (CAS 73128-01-5)
- 4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carbonitrile (CAS 95461-20-4)
- 3,6-Dichloro-2-nitroaniline (CAS 15944-74-8)
- Biotinyl-CBP501 Affinity Peptide trifluoroacetate salt (CAS 2022956-39-2)
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