Nintedanib Impurity 133 CAS CATO-C4X-1814133
| CAS No. | CATO-C4X-1814133 |
| Molecular Formula | C18H28N6O3 |
| Molecular Weight | 376.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Nintedanib Impurity 133 (C18H28N6O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Nintedanib Impurity 133 (CAS CATO-C4X-1814133) is a certified pharmaceutical impurity reference standard with the molecular formula C18H28N6O3 and a molecular weight of 376.45 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nintedanib Impurity 133 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H28N6O3 |
| Molecular Weight | 376.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Nintedanib Standards
- Nintedanib impurity 82 (CAS 2101947-36-6)
- Nintedanib Impurity 56 (CAS CATO-C4X-181456)
- Nintedanib Impurity 57 (CAS 1174335-83-1)
- Nintedanib Impurity 58 (CAS 1160293-24-2)
- Nintedanib Impurity 188 (CAS 2676997-47-8)
- Nintedanib Impurity 34 (CAS 1235004-99-5)
- Nintedanib Impurity 24 (CAS CATO-C4X-181424)
- Nintedanib Impurity 116 (CAS CATO-C4X-1814116)
Recommended Standards
- Mirtazapine Impurity 5 (CAS CATO-C4X-151111)
- Metaraminol Impurity 100 (CAS CATO-C4X-2252100)
- Avibactam Impurity 14 (CAS CATO-C4X-134814)
- Baricitinib D5 (CAS CATO-C4X-2260107)
- Salbutamol Impurity 124 (CAS CATO-C4X-1176124)
- Difenidol Impurity 8 HCl (CAS 17874-62-3)
- Sertraline Impurity 64 (CAS 79560-20-6)
- 4-Bromo-5-(butoxymethyl)-1-(3,3,3-trifluoropropyl)-1H-pyrazole (CAS 1856045-54-9)
- 2-(1-{[2-chloro-5-(trifluoromethyl)phenyl]amino}ethylidene)-2,3-dihydro-1H-indene-1,3-dione (CAS 843636-53-3)
- tert-Butyl [4-(pyridin-2-yl)piperidin-4-yl]methylcarbamate (CAS 1774896-55-7)
- Phenyl(5-(pyrazin-2-yl)-1H-1,2,4-triazol-3-yl)methanamine (CAS 1708370-91-5)
- 2-((tert-Butoxycarbonyl)amino)-2-(2-methoxypyridin-4-yl)acetic acid (CAS 1820606-90-3)
- Iguratimod Impurity 124 (CAS CATO-C4X-1826124)
- Semaglutide impurity 66 (CAS CATO-C4X-222666)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com