Nintedanib Impurity 28 CAS CATO-C4X-181428
| CAS No. | CATO-C4X-181428 |
| Molecular Formula | C24H24N2O4 |
| Molecular Weight | 404.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Nintedanib Impurity 28 (CAS CATO-C4X-181428, C24H24N2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Nintedanib Impurity 28 (C24H24N2O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C24H24N2O4 |
| Molecular Weight | 404.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Nintedanib Standards
- Nintedanib Impurity N4 (CAS 1987887-92-2)
- Nintedanib Impurity 1 (CAS 2410284-89-6)
- Nintedanib Impurity N10 (CAS 1139457-10-5)
- Nintedanib Impurity 116 (CAS CATO-C4X-1814116)
- Nintedanib Impurity 143 (CAS CATO-C4X-1814143)
- Nintedanib Impurity 144 (CAS CATO-C4X-1814144)
- Nintedanib Impurity 145 (CAS CATO-C4X-1814145)
- Nintedanib Impurity 56 (CAS CATO-C4X-181456)
Recommended Standards
- Irinotecan Impurity 60 (CAS CATO-C4X-166760)
- Travoprost Impurity 52 (CAS CATO-C4X-192552)
- Irinotecan Impurity 22 (CAS 124622-81-7)
- Gadobutrol Impurity 107 (CAS 120041-08-9)
- Tenofovir alafenamide Impurity 16 Free base (CAS CATO-C4X-179769)
- Venetoclax Impurity 1 (CAS 1228779-96-1)
- Ammonium Glycyrrhizate Impurity B (CAS CATO-C4X-25377)
- Methyl 3-iodo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylate (CAS 1448862-62-1)
- Triamcinolone Acetonide Impurity 37 (CAS 72559-83-2)
- Febuxostat Impurity 56 (CAS CATO-C4X-116256)
- 2,3-Difluoro-1-isopropoxy-4-methylbenzene (CAS 2624417-77-0)
- 3-Formyl-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxylic acid (CAS 1252672-30-2)
- (5-(3-Chlorophenyl)isoxazol-4-yl)methanol (CAS 430534-65-9)
- Tirzepatide Impurity 50 (CAS CATO-C4X-324050)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com