Nintedanib Impurity N4 CAS 1987887-92-2
| CAS No. | 1987887-92-2 |
| Molecular Formula | C24H21N3O3 |
| Molecular Weight | 399.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Nintedanib Impurity N4 (CAS 1987887-92-2), a pharmacopoeial impurity reference standard (molecular formula C24H21N3O3, MW 399.44 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Nintedanib Impurity N4 (C24H21N3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 399.44 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Nintedanib Impurity N4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H21N3O3 |
| Molecular Weight | 399.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 3 |
Related Nintedanib Standards
- Nintedanib Impurity 28 (CAS CATO-C4X-181428)
- Nintedanib Impurity 116 (CAS CATO-C4X-1814116)
- Nintedanib Impurity 1 (CAS 2410284-89-6)
- Nintedanib Impurity 56 (CAS CATO-C4X-181456)
- Nintedanib Impurity 57 (CAS 1174335-83-1)
- Nintedanib Impurity 58 (CAS 1160293-24-2)
- Nintedanib Impurity N10 (CAS 1139457-10-5)
- Nintedanib Impurity 143 (CAS CATO-C4X-1814143)
Recommended Standards
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- Colchicine EP Impurity B (CAS CATO-C4X-141112)
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- 5-Methyl-2-(pyridin-3-yl)-1,3-thiazol-4-yl 2,3-dichlorobenzoate (CAS 338409-18-0)
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