Paracetamol EP Impurity J CAS 539-03-7
| CAS No. | 539-03-7 |
| Molecular Formula | C8H8ClNO |
| Molecular Weight | 169.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 169.61 g/mol gives Paracetamol EP Impurity J distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Paracetamol EP Impurity J (CAS 539-03-7), a pharmacopoeial impurity reference standard (molecular formula C8H8ClNO, MW 169.61 g/mol) used for the identification and quantification of trace impurities in APIs.
Paracetamol EP Impurity J (C8H8ClNO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8ClNO |
| Molecular Weight | 169.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Paracetamol Standards
- Paracetamol EP Impurity B (CAS 1693-37-4)
- Paracetamol EP Impurity C (CAS 3964-54-3)
- Paracetamol EP Impurity A (CAS 614-80-2)
- Paracetamol EP Impurity G (CAS 34523-34-7)
- Paracetamol (CAS 103-90-2)
- Paracetamol EP Impurity M (CAS 1752-24-5)
- Paracetamol EP Impurity I (CAS 118-93-4)
- Paracetamol EP Impurity E (CAS 99-93-4)
Recommended Standards
- N-(2-chlorophenyl)acetamide (CAS 533-17-5)
- Acetaminophen Impurity 31 (CAS 587-65-5)
- 3＇-Chloroacetanilide (CAS 588-07-8)
- Clenbuterol impurity 11 (CAS 6953-83-9)
- Solifenacin Impurity 42 (CAS 857019-15-9)
- Elacestrant Impurity 10 (CAS CATO-C4X-323210)
- Butamirate Impurity 1 (CAS CATO-C4X-15681)
- 3-Bromo-2-(bromomethyl)-5-chloropyridine (CAS 1227585-58-1)
- 3-dimethylphosphorylpyrrolidine (CAS 2287286-79-5)
- 2-Chloro-5-ethynylpyrimidine (CAS 1196156-89-4)
- N-2-(Hydroxyethyl)-L-valine (CAS 101769-73-7)
- 4-(2-Chloro-6-fluorophenyl)-1-methylpyrrolidin-3-amine (CAS 1706430-62-7)
- tert-butyl N-(cyanomethyl)-N-cyclopropylcarbamate (CAS 1557886-58-4)
- Hexapeptide-9 (CAS 1228371-11-6)
Why CATO?
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