Desloratadine Impurity 48 CAS 119770-61-5
| CAS No. | 119770-61-5 |
| Molecular Formula | C20H21ClN2 |
| Molecular Weight | 324.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Desloratadine Impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Desloratadine Impurity 48 (CAS 119770-61-5) is a certified pharmaceutical impurity reference standard with the molecular formula C20H21ClN2 and a molecular weight of 324.85 g/mol.
Structurally, Desloratadine Impurity 48 (C20H21ClN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 324.85 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H21ClN2 |
| Molecular Weight | 324.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Desloratadine Standards
- Desloratadine Impurity 30 (CAS 183198-48-3)
- Desloratadine Impurity 33 (CAS 38092-90-9)
- Desloratadine Impurity 35 (CAS 38092-88-5)
- Desloratadine Impurity 24 (CAS CATO-C4X-143024)
- Desloratadine Impurity 25 (CAS CATO-C4X-143025)
- Desloratadine Impurity 16 (CAS 1346604-23-6)
- Desloratadine Impurity 17 (CAS 169253-26-3)
- Desloratadine Impurity 22 (CAS 119410-05-8)
Recommended Standards
- N-(6-tert-Butyl-3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-chloropropanamide (CAS 1365963-84-3)
- 2-Chloro-N-[3-cyano-6-(1,1-dimethylpropyl)-4,5,6,7-tetrahydro-1-benzothien-2-yl]acetamide 4799AE 519016-57-0 C16H21ClN2OS (CAS 519016-57-0)
- 551924-38-0 N-(6-tert-Butyl-3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-3-chloropropanamide MFCD01357700 (CAS 551924-38-0)
- Loratadine EP Impurity G (CAS 38092-89-6)
- Chlortetracycline Impurity 24 (CAS CATO-C4X-233024)
- Montelukast EP Impurity H (CAS 906107-37-7)
- Baloxavir Marboxil Impurity 196 (CAS CATO-C4X-2108196)
- Ethyl (2-((6-(adamantan-1-yl)-3-cyano-4-(trifluoromethyl)pyridin-2-yl)thio)acetyl)carbamate (CAS 625376-59-2)
- 2,6-Difluoro-4-(trifluoromethoxy)aniline (CAS 1100833-35-9)
- Melphalan Impurity 37 (CAS CATO-C4X-198837)
- 3-Methyl-4-(trifluoromethyl)pyridin-2(1H)-one (CAS 145705-23-3)
- (dimethylamino)thiourea (CAS 2289-53-4)
- N-Ethyl-3-nitrobenzamide (CAS 26819-11-4)
- Tau Peptide (295-309) trifluoroacetate salt (CAS 330456-46-7)
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