Desloratadine Impurity 30 CAS 183198-48-3
| CAS No. | 183198-48-3 |
| Molecular Formula | C20H21ClN2 |
| Molecular Weight | 324.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Desloratadine Impurity 30 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Desloratadine Impurity 30 (CAS 183198-48-3) is a certified pharmaceutical impurity reference standard with the molecular formula C20H21ClN2 and a molecular weight of 324.85 g/mol.
The molecular framework of Desloratadine Impurity 30 (C20H21ClN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Desloratadine Impurity 30 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H21ClN2 |
| Molecular Weight | 324.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Desloratadine Standards
- Desloratadine Impurity 33 (CAS 38092-90-9)
- Desloratadine Impurity 35 (CAS 38092-88-5)
- Desloratadine Impurity 48 (CAS 119770-61-5)
- Desloratadine Impurity 24 (CAS CATO-C4X-143024)
- Desloratadine Impurity 25 (CAS CATO-C4X-143025)
- Desloratadine Impurity 16 (CAS 1346604-23-6)
- Desloratadine Impurity 17 (CAS 169253-26-3)
- Desloratadine Impurity 22 (CAS 119410-05-8)
Recommended Standards
- Loratadine EP Impurity G (CAS 38092-89-6)
- Roxatidine Impurity 30 (CAS CATO-C4X-121330)
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- Tert-butyl 4-(aminomethyl)-4-(4-chlorophenyl)piperidine-1-carboxylate (CAS 669068-16-0)
- Glipizide Impurity 42 (CAS 73631-58-0)
- Brexpiprazole Impurity 62 (CAS CATO-C4X-113162)
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- 5-methylazepan-4-amine (CAS 1780760-18-0)
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- 2-Fluoro-1-methyl-4-(2,2,2-trifluoroethyl)benzene (CAS 1099597-37-1)
- Tirzepatide Impurity 1 (CAS 2460751-66-8)
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