Desloratadine Impurity 33 CAS 38092-90-9
| CAS No. | 38092-90-9 |
| Molecular Formula | C20H21ClN2 |
| Molecular Weight | 324.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Desloratadine Impurity 33.
Desloratadine Impurity 33 (CAS 38092-90-9) is a certified pharmaceutical impurity reference standard with the molecular formula C20H21ClN2 and a molecular weight of 324.85 g/mol.
Structurally, Desloratadine Impurity 33 (C20H21ClN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 324.85 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H21ClN2 |
| Molecular Weight | 324.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Desloratadine Standards
- Desloratadine Impurity 30 (CAS 183198-48-3)
- Desloratadine Impurity 35 (CAS 38092-88-5)
- Desloratadine Impurity 48 (CAS 119770-61-5)
- Desloratadine Impurity 24 (CAS CATO-C4X-143024)
- Desloratadine Impurity 25 (CAS CATO-C4X-143025)
- Desloratadine Impurity 16 (CAS 1346604-23-6)
- Desloratadine Impurity 17 (CAS 169253-26-3)
- Desloratadine Impurity 22 (CAS 119410-05-8)
Recommended Standards
- Loratadine EP Impurity G (CAS 38092-89-6)
- Roxatidine Impurity 30 (CAS CATO-C4X-121330)
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- Macitentan Impurity 57 (CAS CATO-C4X-117557)
- Acetaminophen Impurity 31 (CAS 587-65-5)
- Nafamostat Impurity 95 HCl (CAS CATO-C4X-133295)
- 2-(3-Chloro-5-fluorophenyl)piperidine (CAS 1257299-98-1)
- 4-Chloro-1-(2-fluoroethyl)-1H-pyrazole-5-carboxylic acid (CAS 1429417-98-0)
- 5-(3,3-Difluoropiperidin-1-yl)-2-(trifluoromethyl)pyridine (CAS 1779136-25-2)
- 1-[(1h-1,2,3,4-tetrazol-5-yl)methyl]piperazine (CAS 1249154-10-6)
- tert-Butyl 2-methyl-3-{[2-(piperidin-1-yl)ethyl]amino}propanoate (CAS 1221342-79-5)
- 5-Chloro-2-fluoro-1-iodo-3-methoxybenzene (CAS 2383196-63-0)
- Acetyl Hexapeptide-38 (CAS 1400634-44-7)
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