Losartan Impurity 1 CAS 79047-41-9
| CAS No. | 79047-41-9 |
| Molecular Formula | C8H13ClN2O |
| Molecular Weight | 188.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 188.65 g/mol gives Losartan Impurity 1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Losartan Impurity 1 (CAS 79047-41-9, C8H13ClN2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Losartan Impurity 1 (C8H13ClN2O) contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Losartan Impurity 1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H13ClN2O |
| Molecular Weight | 188.65 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Losartan Standards
- Losartan EP Impurity D (CAS 83857-96-9)
- Losartan Impurity 20 (CAS 154709-19-0)
- Losartan Impurity 63 (CAS CATO-C4X-168363)
- Losartan Impurity 18 (CAS 158365-99-2)
- Losartan Impurity 23 (CAS 193140-43-1)
- Losartan Potassium EP Impurity E (CAS 120568-11-8)
- Losartan EP Impurity B (CAS 160514-13-6)
- Losartan Impurity 59 (CAS 57246-71-6)
Recommended Standards
- 1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde, 4-chloro- 4-chloro-1h-pyrrolo[2,3-b]pyridine-5-carbaldehyde 4-chloro-1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde, 4-chloro-5-formyl-1h-pyrrolo[2,3-b]pyridine 4-chloro-7-azaindole-5-carboxaldehyde 4-chloro1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde 958230-19-8 anti-N-Cbz-7-hydroxy-2-azabicyclo[2.2.1]heptane (CAS 958230-19-8)
- Allisartan Isoproxil Impurity 7 (CAS CATO-C4X-32177)
- 8-chloroimidazo[1,2-a]pyridine-2-carbaldehyde (CAS 885276-03-9)
- 3-Chlorobiphenyl (CAS 2051-61-8)
- Ilaprazole Impurity 73 (CAS 1378653-43-0)
- Hyoscyamine Impurity 12 (CAS CATO-C4X-343712)
- Rapamycin Aldehyde Degrades Impurity (CAS CATO-C4X-174628)
- 4-((4-(Tert-butyl)phenyl)sulfonyl)piperazin-2-one (CAS 851215-92-4)
- 2-([1,1'-Biphenyl]-4-yl)-2-methylpropan-1-ol (CAS 83493-87-2)
- 3-(3-Methyl-1H-indol-1-yl)isobenzofuran-1(3H)-one (CAS 6308-56-1)
- (S)-2-Amino-N-cyclopropyl-N-((3-(methylthio)pyrazin-2-yl)methyl)propanamide (CAS 1353993-23-3)
- Pentoxifylline Impurity 14 (CAS 16015-11-5)
- 4-Phenylthiomorpholine-3,5-dione 1,1-dioxide (CAS 338421-42-4)
- Insulin Detemir (CAS 169148-63-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com