Hydrochlorothiazide Impurity 52 CAS CATO-C4X-117752
| CAS No. | CATO-C4X-117752 |
| Molecular Formula | C6H7ClN2O5S2 |
| Molecular Weight | 286.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Hydrochlorothiazide Impurity 52 is closely related to a carbohydrate-derived structure, an amide group, a sulfone group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Hydrochlorothiazide Impurity 52 (CAS CATO-C4X-117752) is a high-purity analytical reference standard with the molecular formula C6H7ClN2O5S2 and a molecular weight of 286.71 g/mol.
Structurally, Hydrochlorothiazide Impurity 52 (C6H7ClN2O5S2) contains a carbohydrate-derived structure, an amide group, a sulfone group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 286.71 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H7ClN2O5S2 |
| Molecular Weight | 286.71 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Hydrochlorothiazide Standards
- Hydrochlorothiazide impurity 44 (CAS CATO-C4X-117744)
- Hydrochlorothiazide EP Impurity B (CAS 121-30-2)
- Hydrochlorothiazide Impurity 13 (CAS 99418-26-5)
- Hydrochlorothiazide Impurity 22 (CAS 90794-87-9)
- Hydrochlorothiazide Impurity 56 (CAS CATO-C4X-117756)
- Hydrochlorothiazide Impurity 20 (CAS 82205-98-9)
- Hydrochlorothiazide EP Impurity A (CAS 58-94-6)
- Hydrochlorothiazide (CAS 58-93-5)
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