Tolvaptan Impurity 73 CAS 1316312-24-9
| CAS No. | 1316312-24-9 |
| Molecular Formula | C10H10ClN |
| Molecular Weight | 179.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Tolvaptan Impurity 73 (CAS 1316312-24-9, C10H10ClN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C10H10ClN, Tolvaptan Impurity 73 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 179.65 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H10ClN |
| Molecular Weight | 179.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Tolvaptan Standards
- Tolvaptan Impurity 17 (CAS 1975-51-5)
- Tolvaptan Impurity 49 (CAS 116815-03-3)
- Tolvaptan Impurity N1 (CAS 247237-56-5)
- Tolvaptan Impurity 16 (CAS 160129-45-3)
- Tolvaptan Impurity 33 (CAS 1310357-40-4)
- Tolvaptan Impurity N2 (CAS 30459-70-2)
- Tolvaptan Impurity 19 (CAS 933-88-0)
- Tolvaptan Impurity 39 (CAS 1711-06-4)
Recommended Standards
- n-Cyclopropylbenzenecarbonimidoyl chloride (CAS 869472-58-2)
- Tellurophene (CAS 288-08-4)
- N-(2-Chlorobenzyl)prop-2-yn-1-amine (CAS 892596-58-6)
- 5-(Chloromethyl)-2-(methylthio)thiazole (CAS 1211582-00-1)
- Posaconazole Impurity 16(S,R,S,S) (CAS 213381-02-3)
- Mosapride Impurity 60 (CAS 112913-93-6)
- Belumosudil Impurity 70 (CAS CATO-C4X-298870)
- Pemafibrate Impurity 71 (CAS CATO-C4X-290371)
- Fenofibrate Impurity 33 (CAS 62809-68-1)
- 2-Cyclopentylamino-5-methyl-3-nitropyridine (CAS 1033202-29-7)
- N-(4-morpholinophenyl)benzenesulfonamide (CAS 300816-17-5)
- Methyl 11-aminoundecanoate hydrochloride (CAS 29833-32-7)
- 2-(1-(4-Fluorobenzyl)-3-oxopiperazin-2-yl)acetic acid (CAS 1033600-10-0)
- Semaglutide Impurity 130 (CAS 1188328-40-6)
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