Larotrectinib impurity 6 CAS 1223404-88-3
| CAS No. | 1223404-88-3 |
| Molecular Formula | C16H15F2N5 |
| Molecular Weight | 315.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Larotrectinib impurity 6.
CATO supplies Larotrectinib impurity 6 (CAS 1223404-88-3), a pharmacopoeial impurity reference standard (molecular formula C16H15F2N5, MW 315.32 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, Larotrectinib impurity 6 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 315.32 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Larotrectinib impurity 6 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H15F2N5 |
| Molecular Weight | 315.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Larotrectinib Standards
- Larotrectinib impurity 7 (CAS CATO-C4X-23807)
- Larotrectinib DFP-PPP Impurity (CAS 1223404-89-4)
- Larotrectinib Impurity 17 (CAS CATO-C4X-238017)
- Larotrectinib impurity 4 (CAS 1223404-90-7)
- Larotrectinib impurity 8 (CAS CATO-C4X-23808)
- Larotrectinib Impurity 21 (CAS CATO-C4X-238021)
- Larotrectinib Impurity 2 (CAS 101469-91-4)
- Larotrectinib Impurity 16 (CAS 2699151-02-3)
Recommended Standards
- Olodaterol Impurity 12 (CAS CATO-C4X-194312)
- Pranoprofen Impurity 24 (CAS CATO-C4X-181124)
- Labetalol Impurity 51 (CAS CATO-C4X-246651)
- Naltrexone EP Impurity A (CAS 1007856-83-8)
- Desloratadine Impurity 38 (CAS 7541-16-4)
- Oryzanol Impurity 16 (CAS 286011-30-1)
- Dabigatran Impurity 9 (CAS 1381757-44-3)
- Nadifloxacin Impurity 15 (CAS 64695-81-4)
- N-[2-(propan-2-yl)phenyl]-1,3-benzothiazol-2-amine (CAS 380346-13-4)
- 3-((2,3-Dichlorophenyl)amino)-3-oxopropanoic acid (CAS 95262-11-6)
- Linagliptin impurity 155 (CAS CATO-C4X-1101155)
- N-(2,4-dichloro-5-methoxyphenyl)-5-methyl-1,3,4-thiadiazol-2-amine (CAS 400087-04-9)
- Methyl 15-Methylhexadecanoate (CAS 6929-04-0)
- CGMP Dependent Kinase Inhibitor Peptide (CAS 82801-73-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com