Larotrectinib impurity 4 CAS 1223404-90-7
| CAS No. | 1223404-90-7 |
| Molecular Formula | C16H13F2N5O2 |
| Molecular Weight | 345.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C16H13F2N5O2, Larotrectinib impurity 4 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 345.30 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Larotrectinib impurity 4 (CAS 1223404-90-7), a pharmacopoeial impurity reference standard (molecular formula C16H13F2N5O2, MW 345.30 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Larotrectinib impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H13F2N5O2 |
| Molecular Weight | 345.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Larotrectinib Standards
- Larotrectinib impurity 8 (CAS CATO-C4X-23808)
- Larotrectinib Impurity 17 (CAS CATO-C4X-238017)
- Larotrectinib impurity 6 (CAS 1223404-88-3)
- Larotrectinib impurity 7 (CAS CATO-C4X-23807)
- Larotrectinib DFP-PPP Impurity (CAS 1223404-89-4)
- Larotrectinib Impurity 16 (CAS 2699151-02-3)
- Larotrectinib Impurity 21 (CAS CATO-C4X-238021)
- Larotrectinib (CAS 1223403-58-4)
Recommended Standards
- Nifedipine impurity 38 (CAS CATO-C4X-141038)
- Sulfasalazine Impurity 27 (CAS 501111-03-1)
- Ethyl 2-(2-nitro-4-((3-nitrophenyl)amino)phenyl)acetate (CAS 1033771-61-7)
- 4-Benzyloxy-3-methoxy-6-nitrophenylpyruvic Acid (CAS 2495-79-6)
- Dicyclomine impurity N1 (CAS 109158-77-2)
- Mexiletine EP Impurity D(Enantiomer Mixture) (CAS 26583-71-1)
- Regorafenib Impurity 38 (CAS CATO-C4X-104738)
- 1-(7-Amino-2-methylbenzofuran-3-yl)ethan-1-one (CAS 174186-83-5)
- Relebactam Impurity 13 (CAS CATO-C4X-214413)
- 4-Phenyl-2-pyrrolidone (CAS 1198-97-6)
- 4-(N,N-Diethylamino)butylamine 4-(Diethylamino)butylamine (4-Aminobutyl)diethylamine N,N-Diethyl-1,4-diaminobutane 27431-62-5 (CAS 27431-62-5)
- 4-Methyl-1-(2,2,2-trifluoroacetyl)piperidine-4-carbonitrile (CAS 1443980-84-4)
- (4-Chloro-2-cyclopropylpyrimidin-5-yl)boronic acid (CAS 2225177-67-1)
- HA Peptide (CAS 92000-76-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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