Larotrectinib impurity 8 CAS CATO-C4X-23808
| CAS No. | CATO-C4X-23808 |
| Molecular Formula | C16H13F2N5O2 |
| Molecular Weight | 345.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Larotrectinib impurity 8.
As a process- or degradation-related impurity, Larotrectinib impurity 8 (CAS CATO-C4X-23808, C16H13F2N5O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Larotrectinib impurity 8 (C16H13F2N5O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Larotrectinib impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H13F2N5O2 |
| Molecular Weight | 345.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Larotrectinib Standards
- Larotrectinib impurity 4 (CAS 1223404-90-7)
- Larotrectinib Impurity 17 (CAS CATO-C4X-238017)
- Larotrectinib impurity 6 (CAS 1223404-88-3)
- Larotrectinib impurity 7 (CAS CATO-C4X-23807)
- Larotrectinib DFP-PPP Impurity (CAS 1223404-89-4)
- Larotrectinib Impurity 16 (CAS 2699151-02-3)
- Larotrectinib Impurity 21 (CAS CATO-C4X-238021)
- Larotrectinib (CAS 1223403-58-4)
Recommended Standards
- Ethyl 2-(2-nitro-4-((3-nitrophenyl)amino)phenyl)acetate (CAS 1033771-61-7)
- Nifedipine impurity 38 (CAS CATO-C4X-141038)
- 5-(Methoxycarbonyl)-1,5-dimethyl-2-[2-(trifluoro-methyl)phenyl]-3-pyrrolidinecarboxylic acid (CAS 1052611-53-6)
- Sulfasalazine Impurity 27 (CAS 501111-03-1)
- Foritinib Impurity 6 (CAS CATO-C4X-33106)
- Cholic Acid Impurity 51 (CAS 146340-08-1)
- Topiroxostat Impurity 16 (CAS CATO-C4X-105516)
- 2,4-Hexadiyne (CAS 2809-69-0)
- 6,6-Dimethoxy-1-hexyne (CAS 94059-92-4)
- 3-((Cyclopropylmethyl)sulfonyl)azetidine (CAS 1206970-46-8)
- 1-Allyl-2-imino-5-oxo-N-(1-phenylethyl)-2,5-dihydro-1H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide (CAS 510761-34-9)
- 4-(4-Bromophenyl)-2-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-4-oxobutanoic acid (CAS 94051-80-6)
- 4-(1-(Hydroxymethyl)cyclopropyl)phenol (CAS 251990-49-5)
- Angiotensin II Antipeptide (CAS 121379-63-3)
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