Larotrectinib Impurity 17 CAS CATO-C4X-238017
| CAS No. | CATO-C4X-238017 |
| Molecular Formula | C16H15F2N5O |
| Molecular Weight | 331.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Larotrectinib Impurity 17 (C16H15F2N5O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Larotrectinib Impurity 17 (CAS CATO-C4X-238017) is a certified pharmaceutical impurity reference standard with the molecular formula C16H15F2N5O and a molecular weight of 331.32 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H15F2N5O |
| Molecular Weight | 331.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Larotrectinib Standards
- Larotrectinib impurity 4 (CAS 1223404-90-7)
- Larotrectinib impurity 8 (CAS CATO-C4X-23808)
- Larotrectinib impurity 6 (CAS 1223404-88-3)
- Larotrectinib impurity 7 (CAS CATO-C4X-23807)
- Larotrectinib DFP-PPP Impurity (CAS 1223404-89-4)
- Larotrectinib Impurity 21 (CAS CATO-C4X-238021)
- Larotrectinib Impurity 16 (CAS 2699151-02-3)
- Larotrectinib (CAS 1223403-58-4)
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