Larotrectinib impurity 7 CAS CATO-C4X-23807
| CAS No. | CATO-C4X-23807 |
| Molecular Formula | C16H15F2N5 |
| Molecular Weight | 315.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Larotrectinib impurity 7 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Larotrectinib impurity 7 (CAS CATO-C4X-23807), a pharmacopoeial impurity reference standard (molecular formula C16H15F2N5, MW 315.32 g/mol) used for the identification and quantification of trace impurities in APIs.
Larotrectinib impurity 7 (C16H15F2N5) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Larotrectinib impurity 7 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H15F2N5 |
| Molecular Weight | 315.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Larotrectinib Standards
- Larotrectinib impurity 6 (CAS 1223404-88-3)
- Larotrectinib DFP-PPP Impurity (CAS 1223404-89-4)
- Larotrectinib Impurity 17 (CAS CATO-C4X-238017)
- Larotrectinib impurity 4 (CAS 1223404-90-7)
- Larotrectinib impurity 8 (CAS CATO-C4X-23808)
- Larotrectinib Impurity 21 (CAS CATO-C4X-238021)
- Larotrectinib Impurity 2 (CAS 101469-91-4)
- Larotrectinib Impurity 16 (CAS 2699151-02-3)
Recommended Standards
- Labetalol Impurity 51 (CAS CATO-C4X-246651)
- Olodaterol Impurity 12 (CAS CATO-C4X-194312)
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- Pranoprofen Impurity 24 (CAS CATO-C4X-181124)
- Raloxifene Impurity 24 (CAS CATO-C4X-174324)
- (5Z)-Pioglitazone EP Impurity B (CAS 136401-69-9)
- Atomoxetine Impurity 33 (CAS CATO-C4X-155033)
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- N-[(2E)-3-Phenyl-2-propen-1-yl]cyclopropanamine hydrochloride (CAS 1159700-17-0)
- 4-Oxo-4H-thiopyrano[2,3-b]pyridine-3-carboxylic acid (CAS 148638-63-5)
- Lumasiran (CAS 1834610-13-7)
- 3-Methyl-4-n-propylpyridine (CAS 3478-72-6)
- 1,2,4-Trimethyl-1H-imidazol-5(4H)-one (CAS 32023-93-1)
- Valosin Peptide (VQY), porcine (CAS 99510-37-9)
Why CATO?
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