Nilotinib Impurity 52 CAS CATO-C4X-125652
| CAS No. | CATO-C4X-125652 |
| Molecular Formula | C28H22F3N7O2 |
| Molecular Weight | 545.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nilotinib Impurity 52.
CATO supplies Nilotinib Impurity 52 (CAS CATO-C4X-125652), a pharmacopoeial impurity reference standard (molecular formula C28H22F3N7O2, MW 545.52 g/mol) used for the identification and quantification of trace impurities in APIs.
Nilotinib Impurity 52 (C28H22F3N7O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H22F3N7O2 |
| Molecular Weight | 545.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 7 |
Related Nilotinib Standards
- Nilotinib N-Oxide (CAS 1246817-85-5)
- Nilotinib N-Oxide (Imidazole N-Oxide) (CAS 2139382-75-3)
- Nilotinib Impurity 47 (CAS 1807606-80-9)
- Nilotinib Impurity 53 (CAS CATO-C4X-125653)
- Nilotinib Impurity 11 (CAS CATO-C4X-125611)
- Nilotinib Hydrochloride Monohydrate EP Impurity F (CAS 2119583-24-1)
- Nilotinib Impurity 43 (CAS CATO-C4X-125643)
- Nilotinib-d6 (CAS 1268356-17-7)
Recommended Standards
- N-[3-[[2-[[4-[[1-(2-Fluoroethyl)-3-azetidinyl]amino]-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide (CAS 1375465-09-0)
- 3-Amino-N-[(2H-1,3-benzodioxol-5-yl)methyl]-6-[(3,4-dimethoxyphenyl)methyl]-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 939889-19-7)
- 2-Nitrophenyl β-D-galactopyranoside-6-phosphate cyclohexylammonium salt (CAS 25405-62-3)
- Avelestat (CAS 848141-11-7)
- Gadoteridol Impurity 19 (CAS CATO-C4X-225719)
- Rifamycin Impurity 15 (CAS CATO-C4X-200415)
- Baclofen Impurity 47 (CAS CATO-C4X-101247)
- 3-(6-Amino-2-methylpyridin-3-yl)acrylic acid (CAS 335030-92-7)
- 3-(5-Chlorothiophen-2-yl)propiolic acid (CAS 874513-01-6)
- 3-Chloro-N-ethyl-N-phenylbenzamide (CAS 329058-16-4)
- Methyl 1-(hydroxymethyl)-1h-pyrazole-3-carboxylate (CAS 1001519-16-9)
- (4-Hydroxyphenyl)(pyridin-3-yl)methanone (CAS 35926-15-9)
- Ethyl 3,5-dichloro-4-fluorophenylacetate (CAS 1806302-11-3)
- Semaglutide Impurity 122 (CAS CATO-C4X-2226122)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com