Nilotinib Hydrochloride Monohydrate EP Impurity F CAS 2119583-24-1
| CAS No. | 2119583-24-1 |
| Molecular Formula | C29H24F3N7O |
| Molecular Weight | 543.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Nilotinib Hydrochloride Monohydrate EP Impurity F (CAS 2119583-24-1), a pharmacopoeial impurity reference standard (molecular formula C29H24F3N7O, MW 543.54 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Nilotinib Hydrochloride Monohydrate EP Impurity F (C29H24F3N7O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C29H24F3N7O |
| Molecular Weight | 543.54 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 7 |
Related Nilotinib Standards
- Nilotinib Impurity 11 (CAS CATO-C4X-125611)
- Nilotinib Impurity 43 (CAS CATO-C4X-125643)
- Nilotinib N-Oxide (CAS 1246817-85-5)
- Nilotinib N-Oxide (Imidazole N-Oxide) (CAS 2139382-75-3)
- Nilotinib Impurity 47 (CAS 1807606-80-9)
- Nilotinib Impurity 52 (CAS CATO-C4X-125652)
- Nilotinib Impurity 53 (CAS CATO-C4X-125653)
- Nilotinib-d6 (CAS 1268356-17-7)
Recommended Standards
- 2-(3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-6-iodo-8-methyl-4H-benzo[d][1,3]oxazin-4-one (CAS 736995-63-4)
- Eravacycline Impurity 3(TP-9944） (CAS CATO-C4X-29383)
- 8-(1-(8-(Trifluoromethyl)-7-((4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)ethyl)-8-azabicyclo[3.2.1]octane-3-carboxylic acid (CAS 1624262-38-9)
- [5-(4-Methanesulfonylphenyl)-2-methyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrrol-3-yl]methyl 3-methoxybenzoate (CAS 338749-56-7)
- Pentoxyverine EP Impurity A (CAS 77-55-4)
- Sumatriptan Impurity 6 HCl (CAS 4357-96-4)
- Buspirone EP Impurity A Dibromo salt (CAS 20980-22-7 (free base))
- N-(3,5-Dimethoxyphenyl)-4-fluorobenzamide (CAS 305834-38-2)
- Potassium antimony oxide tartrate (CAS 16039-64-8)
- 2-Amino-8-methoxyquinazoline-4-carboxylic Acid (CAS 1781207-56-4)
- 1,1-Diphenylheptane (CAS 1530-05-8)
- 1-(Difluoromethyl)pyrene (CAS 1186195-16-3)
- 2-Chloro-6-methyl-4-phenyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carbonitrile (CAS 1708401-43-7)
- Tau Peptide (307-321) trifluoroacetate salt (CAS 330456-50-3)
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