Nilotinib Impurity 43 CAS CATO-C4X-125643
| CAS No. | CATO-C4X-125643 |
| Molecular Formula | C30H25F3N6O |
| Molecular Weight | 542.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Nilotinib Impurity 43 (CAS CATO-C4X-125643, C30H25F3N6O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Nilotinib Impurity 43 (C30H25F3N6O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 20.0, corresponding to approximately 20 ring(s) or double-bond equivalent(s). With a molecular weight of 542.55 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Nilotinib Impurity 43 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C30H25F3N6O |
| Molecular Weight | 542.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Nilotinib Standards
- Nilotinib Hydrochloride Monohydrate EP Impurity F (CAS 2119583-24-1)
- Nilotinib Impurity 11 (CAS CATO-C4X-125611)
- Nilotinib N-Oxide (CAS 1246817-85-5)
- Nilotinib N-Oxide (Imidazole N-Oxide) (CAS 2139382-75-3)
- Nilotinib Impurity 47 (CAS 1807606-80-9)
- Nilotinib Impurity 52 (CAS CATO-C4X-125652)
- Nilotinib Impurity 53 (CAS CATO-C4X-125653)
- Nilotinib-d6 (CAS 1268356-17-7)
Recommended Standards
- 2-{[6-(2H-1,3-benzodioxol-5-yl)-3-cyano-4-(trifluoromethyl)pyridin-2-yl]sulfanyl}-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)acetamide (CAS 625377-08-4)
- 1,3-Bis-(1-benzyl-4-trifluoromethyl-piperidin-4-yl)-urea (CAS 2097068-72-7)
- RAF-709, >98% (HPLC) (CAS 1628838-42-5)
- Ponatinib Impurity 11 (CAS CATO-C4X-226911)
- Lidocaine Impurity 79 (CAS CATO-C4X-167979)
- Relebactam Impurity 77 (CAS CATO-C4X-214477)
- Isoprenaline Impurity 28 (CAS CATO-C4X-277528)
- (6-Chloro-2-methoxypyridin-3-yl)methanamine (CAS 1784544-06-4)
- Methyl 5-cyano-5-(2-cyanophenyl)-5-phenylpentanoate (CAS 127999-70-6)
- 2-Bromoethylamine (CAS 107-09-5)
- 1-(2-(4-Methoxyphenoxy)ethyl)-1H-pyrrole-2-carbaldehyde (CAS 883546-33-6)
- 2-Chloro-n-[5-(piperidine-1-sulfonyl)-2-(propan-2-yloxy)phenyl]acetamide (CAS 879362-86-4)
- N-Methyl-3-chlorobenzylamine hydrobromide, 98% (CAS 1185292-73-2)
- D-Val23-Tirzepatide (CAS CATO-CPTD788911)
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