Tofacitinib Impurity 72 CAS 1260614-73-0
| CAS No. | 1260614-73-0 |
| Molecular Formula | C13H19N5 |
| Molecular Weight | 245.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tofacitinib Impurity 72 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Tofacitinib Impurity 72 (CAS 1260614-73-0) is a certified pharmaceutical impurity reference standard with the molecular formula C13H19N5 and a molecular weight of 245.32 g/mol.
Structurally, Tofacitinib Impurity 72 (C13H19N5) contains a nitrogen-containing heterocyclic scaffold, a nitrile group. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 245.32 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H19N5 |
| Molecular Weight | 245.32 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity N2 (CAS 1206825-36-6)
- Tofacitinib Impurity 10 (CAS 2097982-05-1)
- Tofacitinib Impurity 227 (CAS CATO-C4X-1079227)
- Tofacitinib Impurity 41 (CAS CATO-C4X-107941)
- Tofacitinib Impurity 42 (CAS CATO-C4X-107942)
- Tofacitinib Impurity 6 (CAS 477600-74-1)
- Tofacitinib Impurity 161 (CAS 1638499-36-1)
- Tofacitinib Impurity N1 (CAS 1782226-06-5)
Recommended Standards
- Agomelatine Impurity 19 (CAS 1352139-51-5)
- Agomelatine Impurity 20 (CAS 178677-39-9)
- Atorvastatin Impurity 167 (CAS CATO-C4X-1132167)
- Perindopril Impurity 31 (CAS CATO-C4X-125231)
- Mezlocillin Impurity 4 (CAS CATO-C4X-18314)
- Tobramycin Impurity N2 (CAS 111170-72-0)
- Carfilzomib Impurity 87 (CAS CATO-C4X-102287)
- 2-(2-Bromo-4-(difluoromethyl)-6-iodopyridin-3-yl)acetic acid (CAS 1804842-01-0)
- n-(2-Methoxybenzyl)-1-(1-methyl-1h-pyrazol-5-yl)methanamine (CAS 1006438-71-6)
- 5-Bromo-6-nitro-1,3-benzodioxole (CAS 7748-58-5)
- ethyl 4-nitro-1H-pyrrole-2-carboxylate (CAS 5930-92-7)
- (1H-indol-3-yl)(phenyl)methanone (CAS 15224-25-6)
- 4-Chloro-1-(pyridazin-3-yl)-1H-pyrazolo[3,4-d]pyrimidine (CAS 1697967-83-1)
- Protein Kinase C (alpha) Peptide (CAS 159939-84-1)
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