Tofacitinib Impurity N1 CAS 1782226-06-5
| CAS No. | 1782226-06-5 |
| Molecular Formula | C12H21NO4 |
| Molecular Weight | 243.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Tofacitinib Impurity N1 (C12H21NO4) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Tofacitinib Impurity N1 (CAS 1782226-06-5, C12H21NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tofacitinib Impurity N1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H21NO4 |
| Molecular Weight | 243.30 g/mol |
| Appearance | White to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1994 |
| Nitrogen Atoms | 1 |
Related Tofacitinib Standards
- Tofacitinib Impurity 161 (CAS 1638499-36-1)
- Tofacitinib Impurity N2 (CAS 1206825-36-6)
- Tofacitinib Impurity 10 (CAS 2097982-05-1)
- Tofacitinib Impurity 227 (CAS CATO-C4X-1079227)
- Tofacitinib Impurity 41 (CAS CATO-C4X-107941)
- Tofacitinib Impurity 42 (CAS CATO-C4X-107942)
- Tofacitinib Impurity 6 (CAS 477600-74-1)
- Tofacitinib Impurity 72 (CAS 1260614-73-0)
Recommended Standards
- 2-(3-{[(tert-butoxy)carbonyl]amino}cyclopentyl)acetic acid (CAS 1781824-30-3)
- 2-(1-(Tert-butoxycarbonyl)pyrrolidin-2-yl)propanoic acid (CAS 1784129-64-1)
- 2-(1-(Tert-butoxycarbonyl)azetidin-3-yl)butanoic acid (CAS 1780325-82-7)
- Ethyl 4-hydroxy-1-oxa-9-azaspiro[5.5]Undecane-9-carboxylate (CAS 1785764-72-8)
- Tetracaine Impurity 21 (CAS CATO-C4X-192321)
- Rimegepant Impurity 121 (CAS CATO-C4X-2487121)
- Mianserin Impurity 95 (CAS CATO-C4X-136995)
- 1,1'-(9-(2-(Isopropylamino)ethyl)-9H-carbazole-3,6-diyl)diethanone hydrochloride (CAS 1197397-89-9)
- (3-(Hydroxypyrrolidin-1-yl)acetic acid (CAS 258530-57-3)
- 2-(2-Ethoxybenzylidene)benzo[4,5]imidazo[2,1-b]thiazol-3(2H)-one (CAS 30065-04-4)
- Ethyl 2-amino-7-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate (CAS 2270908-42-2)
- Tadalafil Impurity 16 (CAS 629652-44-4)
- 6-Fluorothiazolo[5,4-b]pyridin-2(1H)-one (CAS 1003945-43-4)
- Cholecystokinin Octapeptide (desulfated) (H-2070.0005) (CAS 198483-36-2)
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