Retigabine Impurity 3 CAS 1263404-73-4
| CAS No. | 1263404-73-4 |
| Molecular Formula | C19H22FN3O4 |
| Molecular Weight | 375.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Retigabine Impurity 3 (CAS 1263404-73-4) is a certified pharmaceutical impurity reference standard with the molecular formula C19H22FN3O4 and a molecular weight of 375.39 g/mol.
Retigabine Impurity 3 (C19H22FN3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C19H22FN3O4 |
| Molecular Weight | 375.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Retigabine Standards
- Retigabine Impurity 2 (CAS CATO-C4X-13142)
- Retigabine impurity 11 (CAS CATO-C4X-13151)
- Retigabine impurity 16 (CAS CATO-C4X-13156)
- Retigabine impurity 13 (CAS CATO-C4X-13153)
- Retigabine (CAS 150812-12-7)
- Retigabine Impurity 1 (CAS CATO-C4X-13141)
- Retigabine impurity 8 (CAS CATO-C4X-13148)
- Retigabine impurity 9 (CAS CATO-C4X-13149)
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