Demeclocycline CAS 127-33-3
| CAS No. | 127-33-3 |
| Molecular Formula | C21H21ClN2O8 |
| Molecular Weight | 464.85 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Demeclocycline (C21H21ClN2O8) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Demeclocycline (CAS 127-33-3) is a high-purity analytical reference standard with the molecular formula C21H21ClN2O8 and a molecular weight of 464.85 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H21ClN2O8 |
| Molecular Weight | 464.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Demeclocycline Standards
- Demeclocycline EP Impurity B (CAS 14206-59-8)
- Demeclocycline EP Impurity F (CAS CATO-C4X-16086)
- Demeclocycline EP Impurity G (CAS 22688-73-9)
- Demeclocycline EP Impurity A (CAS 987-02-0)
- Demeclocycline EP Impurity C (CAS 129044-45-7)
- Demeclocycline impurity 12 (CAS CATO-C4X-160812)
- Demeclocycline Impurity 10 (CAS CATO-C4X-160810)
- Demeclocycline EP Impurity E (CAS 4496-85-9)
Recommended Standards
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