Ketoconazole Impurity 7 CAS 172032-21-2
| CAS No. | 172032-21-2 |
| Molecular Formula | C11H12Cl2O3 |
| Molecular Weight | 263.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 263.12 g/mol gives Ketoconazole Impurity 7 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ketoconazole Impurity 7 (CAS 172032-21-2) is a certified pharmaceutical impurity reference standard with the molecular formula C11H12Cl2O3 and a molecular weight of 263.12 g/mol.
The molecular framework of Ketoconazole Impurity 7 (C11H12Cl2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Ketoconazole Impurity 7 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H12Cl2O3 |
| Molecular Weight | 263.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
| Halogen Content | Cl-containing |
Related Ketoconazole Standards
- Ketoconazole Impurity 21 (CAS 129643-72-7)
- Ketoconazole Impurity 23 (CAS 29098-85-9)
- Ketoconazole Impurity 24 (CAS CATO-C4X-147224)
- Ketoconazole Impurity 17 (CAS 67914-60-7)
- Ketoconazole Impurity 15 (CAS 581806-59-9)
- Ketoconazole Impurity 22 (CAS CATO-C4X-147222)
- Ketoconazole Impurity 25 (CAS CATO-C4X-147225)
- Ketoconazole Impurity 19 (CAS CATO-C4X-147219)
Recommended Standards
- Posaconazole Impurity 270 (CAS 55743-71-0)
- Dotinurad Impurity 130 (CAS 1368227-41-1)
- Chlorphenamine Impurity 27 (CAS 339114-86-2)
- 2,4-Db-Methyl Ester (CAS 18625-12-2)
- Ceftazidime EP Impurity F(HCl) (CAS 628-13-7)
- Azilsartan Impurity 124 (CAS CATO-C4X-1096124)
- Mitoxantrone EP Impurity D (CAS 137132-70-8)
- 2-(5-Methylthiophen-2-yl)oxirane (CAS 73099-66-8)
- 4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-methyl-1H-pyrazol-5-amine (CAS 1152534-41-2)
- 3-Phenyl-2H-benzo[b][1,4]thiazine-2-carboxylic acid (CAS 1160264-28-7)
- 2-(4-Iodo-1H-pyrazol-3-yl)acetonitrile (CAS 1707359-71-4)
- 2-(Dimethylamino)quinoline-4-carbonitrile (CAS 1354951-88-4)
- (4-Fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol (CAS 1241914-87-3)
- D-[γ-Glu](Side Chain)-Semaglutide (CAS CATO-C4X-2226254)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com