Aspirin Impurity 12 CAS 13110-96-8
| CAS No. | 13110-96-8 |
| Molecular Formula | C9H8O4 |
| Molecular Weight | 180.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Aspirin Impurity 12 (CAS 13110-96-8) is a certified pharmaceutical impurity reference standard with the molecular formula C9H8O4 and a molecular weight of 180.16 g/mol.
The molecular framework of Aspirin Impurity 12 (C9H8O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Aspirin Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8O4 |
| Molecular Weight | 180.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
Related Aspirin Standards
- Aspirin Impurity 21 (CAS 606-19-9)
- Aspirin Impurity 22 (CAS 601-97-8)
- Aspirin Impurity 13 (CAS 57009-12-8)
- Aspirin Impurity 17 (CAS 77527-00-5)
- Aspirin Impurity 25 (CAS 38160-63-3)
- Aspirin Impurity 8 (CAS 18698-59-4)
- Aspirin Impurity A (CAS 99-96-7)
- Aspirin Impurity C / Mesalazine EP Impurity H (CAS 69-72-7)
Recommended Standards
- Nafamostat Impurity 15 (CAS 6306-25-8)
- Deferasirox Impurity 20 (CAS CATO-C4X-143820)
- Dimenhydrinate EP Impurity A (CAS 58-55-9)
- Mycophenolate Impurity 20 (CAS 27979-57-3)
- Iguratimod Impurity 87 (CAS CATO-C4X-182687)
- Sacubitril impurity 51 (CAS CATO-C4X-280951)
- Raltitrexed Impurity 37 (CAS CATO-C4X-138637)
- N-(5-(tert-butyl)-1,3,4-thiadiazol-2-yl)-2-chloronicotinamide (CAS 866010-66-4)
- 1-(2-Aminoethyl)pyrrolidin-2-one hydrochloride (CAS 92885-03-5)
- N-acetyl-N-(benzyloxy)benzamide (CAS 22421-17-6)
- 4-Bromo-N-(3-fluoro-2-methylphenyl)benzenesulfonamide (CAS 1284698-48-1)
- 2-[(4-Amino-2-fluorophenyl)amino]ethanol (CAS 1039868-68-2)
- N-Methyl-1-(2-quinoxalinyl)methanamine oxalate (CAS 1185033-05-9)
- Tetrapeptide-30/Tegopep (CAS 1036207-61-0)
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