Netupitant Impurity 25 CAS 1314651-44-9
| CAS No. | 1314651-44-9 |
| Molecular Formula | C12H10F6O2 |
| Molecular Weight | 300.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Netupitant Impurity 25 (C12H10F6O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 300.20 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Netupitant Impurity 25 (CAS 1314651-44-9) is a certified pharmaceutical impurity reference standard with the molecular formula C12H10F6O2 and a molecular weight of 300.20 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10F6O2 |
| Molecular Weight | 300.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Netupitant Standards
- Netupitant Impurity 24 (CAS 1314722-26-3)
- Netupitant Impurity 44 (CAS CATO-C4X-122344)
- Netupitant Impurity 51 (CAS CATO-C4X-122351)
- Netupitant Impurity 63 (CAS CATO-C4X-122363)
- Netupitant Impurity 16 (CAS 2973069-91-7)
- Netupitant Impurity 17 (CAS CATO-C4X-122317)
- Netupitant Impurity 18 (CAS CATO-C4X-122318)
- Netupitant Impurity 19 (CAS CATO-C4X-122319)
Recommended Standards
- 2-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropanoic acid (CAS 289686-70-0)
- Ethane-1,1-diylbis(butylselane) (CAS 26822-79-7)
- 5-(Trifluoromethyl)thiophen-3-yl trifluoromethanesulfonate (CAS 827322-77-0)
- Abemaciclib Impurity 50 (CAS CATO-C4X-293750)
- Finerenone Impurity 232 (CAS CATO-C4X-2880232)
- Lacosamide Impurity 45 (CAS CATO-C4X-183045)
- Dapagliflozin Impurity 159 (CAS CATO-C4X-1138159)
- 3-Methylfuran-2-carbohydrazide (CAS 52541-78-3)
- 948294-24-4 5-Chloro-8-methylquinoline-3-carboxylic acid DTXSID00589108 (CAS 948294-24-4)
- (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(2,4-dimethoxyphenyl)butanoic acid (CAS 1260616-55-4)
- tert-butyl (3S,4R)-3-azido-4-fluoro-pyrrolidine-1-carboxylate (CAS 913743-09-6)
- (4-Methylpyrrolidin-3-yl)methanamine (CAS 107610-62-8)
- Peramivir Impurity 72 (CAS 251327-00-1)
- Staphylococcus Aureus Protein A (SpA)-Derived Peptide (H-2228.0005) (CAS 144979-26-0)
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