Tolvaptan Impurity 19 CAS 933-88-0
| CAS No. | 933-88-0 |
| Molecular Formula | C8H7ClO |
| Molecular Weight | 154.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Tolvaptan Impurity 19 (CAS 933-88-0), a pharmacopoeial impurity reference standard (molecular formula C8H7ClO, MW 154.59 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Tolvaptan Impurity 19 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 154.59 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7ClO |
| Molecular Weight | 154.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Tolvaptan Standards
- Tolvaptan Impurity 39 (CAS 1711-06-4)
- Tolvaptan Impurity 18 (CAS 2486-75-1)
- Tolvaptan Impurity 21 (CAS 118-90-1)
- Tolvaptan Impurity 73 (CAS 1316312-24-9)
- Tolvaptan Impurity 17 (CAS 1975-51-5)
- Tolvaptan Impurity 49 (CAS 116815-03-3)
- Tolvaptan Impurity N1 (CAS 247237-56-5)
- Tolvaptan Impurity 16 (CAS 160129-45-3)
Recommended Standards
- Roxithromycin Impurity 15 (CAS 89268-03-1)
- Acetaminophen Impurity 32 (CAS 874-60-2)
- 2'-Chloroacetophenone (CAS 2142-68-9)
- Aprepitant Impurity 35 (CAS 74974-54-2)
- Urapidil Impurity 108 (CAS CATO-C4X-1924108)
- Ethacridine Impurity C53 (CAS 20304-70-5)
- Remdesivir Impurity 9 (CAS 1191237-80-5)
- 2,3-Dihydrobenzo[b][1,4]dioxine-2-carbaldehyde (CAS 64179-67-5)
- (R)-(-)-1-(9-Anthryl)-2,2,2-trifluoroethanol (R)-(-)-2,2,2-Trifluoro-1-(9-anthryl)ethanol (R)-(-)-alpha-(Trifluoromethyl)-9-anthracenemethanol 53531-34-3 T1520 (CAS 53531-34-3)
- 1-[difluoro(4-nitrophenyl)methyl]-4-nitrobenzene (CAS 339-24-2)
- N-(4-Fluoro-2-methylphenyl)-3-methylbenzamide (CAS 852130-18-8)
- Methyl 4-chloro-6-methoxynicotinate (CAS 848953-45-7)
- Ethyl 3-amino-4-(4-methylpiperazin-1-yl)benzoate (CAS 1220036-10-1)
- Peptide 438 (CAS CATO-CPTD788438)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com