Aprepitant Impurity 7 CAS 1242175-34-3
| CAS No. | 1242175-34-3 |
| Molecular Formula | C23H21F7N4O3 |
| Molecular Weight | 534.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Aprepitant Impurity 7 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Aprepitant Impurity 7 (CAS 1242175-34-3), a pharmacopoeial impurity reference standard (molecular formula C23H21F7N4O3, MW 534.43 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Aprepitant Impurity 7 (C23H21F7N4O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Aprepitant Impurity 7 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H21F7N4O3 |
| Molecular Weight | 534.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Aprepitant Standards
- Aprepitant (CAS 170729-80-3)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant Impurity 3 (CAS 172822-28-5)
- Aprepitant Impurity 4 (CAS 172822-29-6)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
- Aprepitant Impurity 6 (CAS 170902-81-5)
- Aprepitant impurity 66 (CAS CATO-C4X-114166)
Recommended Standards
- Aprepitant Impurity 9 (CAS CATO-C4X-11419)
- Fmoc-Gln-OPfp (CAS 86061-00-9)
- 9,9'-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-phenylene)bis(9H-carbazole) (CAS 1082549-89-0)
- Diquinoxalino[2,3-a:2',3'-c]phenazine-2,3,8,9,14,15-hexacarbonitrile (CAS 887401-68-5)
- Eplerenone Impurity 43 (CAS CATO-C4X-163043)
- Haloperidol Decanoate EP Impurity D (CAS 1797008-46-8)
- Flumetasone Impurity 17 (CAS CATO-C4X-191017)
- Cyclopropyl(4-isopropylphenyl)methanamine (CAS 535925-87-2)
- E-Cefepime (CAS CATO-C4X-119334)
- (6-Bromo-2-methoxypyridin-3-yl)methanamine (CAS 1802489-58-2)
- (S)-1-(5-bromopyridin-3-yl)-2,2,2-trifluoroethan-1-amine hydrochloride (CAS 1391393-70-6)
- Ethyl 1-isopropyl-1H-pyrazole-3-carboxylate (CAS 1007514-99-9)
- Ethyl 3'-hydroxy-4'-oxo-2,3,4',5,6,6',7',8'-octahydrospiro[pyran-4,9'-pyrido[1,2-a]pyrimidine]-2'-carboxylate (CAS 937262-59-4)
- 81988-89-8 UH11FDQ454 Ramoplanin A(sub 3) Ramoplanin A3 (S)-2-(3-Chloro-4-hydroxyphenyl)-N-(N(sup 2)-((2Z,4Z)-8-methyl-2,4-nonadienoyl)-(S)-asparaginyl-(2S,3S)-3-hydroxyasparaginyl-(R)-2-(p-hydroxyphenyl)glycyl-(R)-ornithyl-(2R,3R)-allothreonyl-2-(p-hydroxyphenyl)glycyl-2-(p-hydroxyphenyl)glycyl-(2S,3S)-allothreonyl-(S)-phenylalanyl-(R)-ornithyl-(S)-2-(p-((2-O-alpha-D-mannopyranosyl-alpha-D-mannopyranosyl)oxy)phenyl)glycyl-(2R,3R)-allothreonyl-(S)-2-(p-hydroxyphenyl)glycylglycyl-(S)-leucyl-(R)-alanyl)glycine psi1-lactone Ramoplanin A 1 (peptide moiety), 1-(N(sup 2)-methyl-1-oxo-2,4-nonadienyl)-L-asparagine)-11-(L-2-(4-((2-O-alpha-D-mannopyranosyl-alpha-D-mannopyranosyl)oxy)phenyl)glycine)-, (Z,Z)- UNII-UH11FDQ454 (CAS 81988-89-8)
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