Aprepitant Impurity 38 CAS 127852-28-2
| CAS No. | 127852-28-2 |
| Molecular Formula | C10H8F6O |
| Molecular Weight | 258.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Aprepitant Impurity 38 (CAS 127852-28-2, C10H8F6O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Aprepitant Impurity 38 (C10H8F6O) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8F6O |
| Molecular Weight | 258.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
Related Aprepitant Standards
- Aprepitant Impurity 32 (CAS 225920-05-8)
- Aprepitant Impurity 33 (CAS 1265177-56-7)
- Aprepitant Impurity 45 (CAS 364-47-6)
- Aprepitant Impurity 76 (CAS CATO-C4X-114176)
- Aprepitant impurity 28 (CAS 479679-98-6)
- Aprepitant Impurity 34 (CAS 30071-93-3)
- Aprepitant Impurity 75 (CAS 240489-98-9)
- Aprepitant impurity 50 (CAS 349-59-7)
Recommended Standards
- N1-(5-bromopyridin-2-yl)pentane-1,5-diamine (CAS 199522-81-1)
- 4-(2,2,3,3-Tetrafluoropropoxy)Phthalonitrile (CAS 121190-46-3)
- Hexafluoro-2-(4-methylphenyl)propan-2-ol (CAS 2010-61-9)
- 2-(4-fluorophenyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 1239765-81-1)
- Norepinephrine impurity 152 (CAS 490-90-4)
- Vonoprazan Impurity 150 (CAS 312307-69-0)
- Emedastine Impurity 44 (CAS CATO-C4X-226744)
- 1-Ethyl-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (CAS 875224-04-7)
- 1-(4-Methylpiperidin-1-yl)-4-phenylbutan-1-one (CAS 432494-63-8)
- 3-amino-5-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile (CAS 42754-62-1)
- Ethyl 2,2-Difluoro-2-mesitylacetate (CAS 1436389-43-3)
- 1-(Bromomethyl)-2-chloro-3-nitrobenzene (CAS 89642-16-0)
- Lubiprostone impurity 6 (CAS 945651-35-4)
- Vialox Peptide(Pentapeptide-3) (CAS 135679-88-8)
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