Aprepitant Impurity 33 CAS 1265177-56-7
| CAS No. | 1265177-56-7 |
| Molecular Formula | C10H8F6O |
| Molecular Weight | 258.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Aprepitant Impurity 33 (C10H8F6O) contains a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Aprepitant Impurity 33 (CAS 1265177-56-7) is a certified pharmaceutical impurity reference standard with the molecular formula C10H8F6O and a molecular weight of 258.16 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8F6O |
| Molecular Weight | 258.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Aprepitant Standards
- Aprepitant Impurity 32 (CAS 225920-05-8)
- Aprepitant Impurity 38 (CAS 127852-28-2)
- Aprepitant Impurity 45 (CAS 364-47-6)
- Aprepitant Impurity 76 (CAS CATO-C4X-114176)
- Aprepitant impurity 28 (CAS 479679-98-6)
- Aprepitant Impurity 34 (CAS 30071-93-3)
- Aprepitant Impurity 75 (CAS 240489-98-9)
- Aprepitant impurity 50 (CAS 349-59-7)
Recommended Standards
- N1-(5-bromopyridin-2-yl)pentane-1,5-diamine (CAS 199522-81-1)
- Hexafluoro-2-(4-methylphenyl)propan-2-ol (CAS 2010-61-9)
- 5,6,7,8-Tetrahydronaphthalene-2-boronic Acid Pinacol Ester (CAS 627526-54-9)
- 4-(2,2,3,3-Tetrafluoropropoxy)Phthalonitrile (CAS 121190-46-3)
- Rosiglitazone Impurity 3 (CAS 2142519-15-9)
- Teprenone Impurity 29 (CAS CATO-C4X-208129)
- Rimegepant Impurity 146 (CAS CATO-C4X-2487146)
- 1-(2-(3-Bromo-5-fluorophenoxy)ethyl)pyrrolidine (CAS 1516187-39-5)
- Ethyl 5-chloro-1,2,4-oxadiazole-3-carboxylate (CAS 1393552-64-1)
- Itraconazole N-Formyl-Ethlene Impurity (CAS 1199350-00-9)
- 3-((1-(Tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)benzoic acid (CAS 627097-16-9)
- N-(3-Chloro-4-methylphenyl)morpholine-4-carboxamide (CAS 196876-37-6)
- 1-(1-(2-Chlorobenzyl)-3,5-dimethyl-1h-pyrazol-4-yl)-N-methylmethanamine (CAS 956199-27-2)
- Semaglutide impurity 29 (CAS 110990-08-4)
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