Bictegravir Related Compound C001/Dolutegravir Intermediate-1 CAS 1335210-23-5
| CAS No. | 1335210-23-5 |
| Molecular Formula | C13H17NO8 |
| Molecular Weight | 315.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Bictegravir Related Compound C001/Dolutegravir Intermediate-1 (CAS 1335210-23-5, C13H17NO8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Bictegravir Related Compound C001/Dolutegravir Intermediate-1 (C13H17NO8) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Bictegravir Related Compound C001/Dolutegravir Intermediate-1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H17NO8 |
| Molecular Weight | 315.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 1 |
Related Bictegravir Standards
- Bictegravir Impurity 2 (CAS CATO-C4X-21812)
- Bictegravir (CAS 1611493-60-7)
- Bictegravir Impurity 10(2R,5S,13aS) (CAS CATO-C4X-218110)
- Bictegravir Impurity 8(2S,5R,13aS) (CAS CATO-C4X-21818)
- Bictegravir Impurity 9(2R,5R,13aR) (CAS CATO-C4X-21819)
- Bictegravir-15N, d2 (CAS CATO-C4X-21811)
- Bictegravir Related Compound 2 (CAS 1110772-05-8)
- Bictegravir impurity 11 (CAS CATO-C4X-218111)
Recommended Standards
- Avenanthramide C (CAS 116764-15-9)
- Ethyl 2-(6-ethyl-3-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate (CAS 1018125-89-7)
- Carbazochrome impurity 48 (CAS CATO-C4X-229148)
- N-(2-Aminoethyl)-5-oxo-1-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide (CAS 1081138-72-8)
- Vonoprazan Impurity 135 (CAS 55717-46-9)
- Edaravone impurity 41 (CAS CATO-C4X-106241)
- Atrasentan Impurity 171 (CAS 1059051-90-9)
- 4-Bromo-3-(ethoxymethyl)-1-ethyl-1H-pyrazole (CAS 1856018-98-8)
- 2-(5-Ethoxy-1H-indol-3-yl)acetic acid (CAS 857809-50-8)
- 4-Bromo-1-(4-fluoro-2-nitrophenyl)-1h-pyrazole (CAS 1171922-57-8)
- 1,4-Bis(4-chlorophenyl)-3-methyl-1H-pyrazol-5-amine (CAS 321391-75-7)
- 6-(Morpholinosulfonyl)pyridin-3-amine (CAS 1215925-33-9)
- N2-(2-Methoxyethyl)-N4-phenylpteridine-2,4-diamine (CAS 946298-72-2)
- Peptide Impurity 81 TFA (CAS CATO-CPTD788581)
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