Bictegravir Impurity 9(2R,5R,13aR) CAS CATO-C4X-21819
| CAS No. | CATO-C4X-21819 |
| Molecular Formula | C21H18F3N3O5 |
| Molecular Weight | 449.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Bictegravir Impurity 9(2R,5R,13aR) (CAS CATO-C4X-21819, C21H18F3N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Bictegravir Impurity 9(2R,5R,13aR) (C21H18F3N3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Bictegravir Impurity 9(2R,5R,13aR) under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H18F3N3O5 |
| Molecular Weight | 449.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Bictegravir Standards
- Bictegravir (CAS 1611493-60-7)
- Bictegravir Impurity 10(2R,5S,13aS) (CAS CATO-C4X-218110)
- Bictegravir Impurity 8(2S,5R,13aS) (CAS CATO-C4X-21818)
- Bictegravir-15N, d2 (CAS CATO-C4X-21811)
- Bictegravir Related Compound C001/Dolutegravir Intermediate-1 (CAS 1335210-23-5)
- Bictegravir Impurity 2 (CAS CATO-C4X-21812)
- Bictegravir Related Compound 2 (CAS 1110772-05-8)
- Bictegravir impurity 11 (CAS CATO-C4X-218111)
Recommended Standards
- 3-((3,5-Bis(trifluoromethyl)phenyl)amino)-4-(((1R,2R)-2-(dimethylamino)cyclohexyl)amino)cyclobut-3-ene-1,2-dione (CAS 1211565-07-9)
- 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(1S,2S)-2-(dimethylamino)cyclohexyl]amino]-3-cyclobutene-1,2-dione (CAS 1263205-96-4)
- 2-((4-Allyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-bromo-4-methylphenyl)acetamide (CAS 587013-88-5)
- Sunitinib Impurity 79 (CAS CATO-C4X-133379)
- Telmisartan EP Impurity C (CAS 144702-26-1)
- Vonoprazan Impurity N20 (CAS 2416241-98-8)
- Clopidogrel Impurity 130 (CAS CATO-C4X-1029130)
- 1,2,4-Triazin-5-amine (CAS 822-69-5)
- methyl 3-amino-3-(2-fluorophenyl)butanoate (CAS 1511048-32-0)
- 3-Methoxy-2-methyl-N-(2-(pyridin-4-yl)ethyl)-2H-indazole-6-carboxamide (CAS 1421491-37-3)
- (5-amino-1-butyl-1H-1,3-benzodiazol-2-yl)methanol (CAS 1224322-32-0)
- 5-[(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)amino]-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 303151-70-4)
- 6-(Trifluoromethyl)pyrimidine-4,5-diamine (CAS 23663-20-9)
- Semaglutide impurity 261 (CAS CATO-C4X-2226261)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com