Avacopan Impurity 2 CAS 1346623-07-1
| CAS No. | 1346623-07-1 |
| Molecular Formula | C22H25FN2O3 |
| Molecular Weight | 384.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Avacopan Impurity 2 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 384.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Avacopan Impurity 2 (CAS 1346623-07-1), a pharmacopoeial impurity reference standard (molecular formula C22H25FN2O3, MW 384.44 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Avacopan Impurity 2 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H25FN2O3 |
| Molecular Weight | 384.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Avacopan Standards
- Avacopan Impurity 6 (CAS 2763538-64-1)
- Avacopan Impurity 5 (CAS 1346623-09-3)
- Avacopan Impurity 4 (CAS 1346623-05-9)
- Avacopan Impurity 10 (CAS CATO-C4X-294510)
- Avacopan (CAS 1346623-17-3)
- Avacopan Impurity 12 (CAS CATO-C4X-294512)
- Avacopan impurity 7 (CAS 1257868-45-3)
- Avacopan Impurity 9 (CAS CATO-C4X-29459)
Recommended Standards
- Rabeprazole-d3 Sodium Salt (CAS CATO-C4X-112147)
- Ethyl 4-((3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5-yl)amino)-4-oxobutanoate (CAS 1020489-39-7)
- 6 β-Fluoro-21-hydroxypregna-1,4,9(11),16-Tetraene-3,20-dione 21-Acetate (CAS 60864-52-0)
- 7,7'-(Thiophen-2-ylmethylene)bis(quinolin-8-ol) (CAS 105192-48-1)
- Isoprenaline impurity 21 (CAS CATO-C4X-277521)
- Dobutamine Impurity 8 (CAS 14165-67-4)
- Isoproturon Impurity 2 (CAS 70214-90-3)
- 4-Chloro-3-methoxy-1,2-thiazole-5-carbaldehyde (CAS 2089257-62-3)
- K201 (CAS 1026399-42-7)
- 2-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 3-methyl-4-oxo-, 1,1-dimethylethyl ester, (3S)- (CAS 1801766-83-5)
- 2-(4-(Difluoromethyl)-5-iodo-6-methoxypyridin-3-yl)acetic acid (CAS 1805417-49-5)
- N-methylpyrimidin-2-amine (CAS 931-61-3)
- 5-Isopropylpyrimidin-2-ol hydrochloride (CAS 1401426-12-7)
- Peptide 437 (CAS CATO-CPTD788437)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com