Dolutegravir Impurity 1 CAS 1357289-29-2
| CAS No. | 1357289-29-2 |
| Molecular Formula | C20H19F2N3O5 |
| Molecular Weight | 419.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Dolutegravir Impurity 1 (CAS 1357289-29-2, C20H19F2N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C20H19F2N3O5, Dolutegravir Impurity 1 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 419.38 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H19F2N3O5 |
| Molecular Weight | 419.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >80% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir (CAS 1051375-16-6)
- Dolutegravir Impurity 11 (CAS 1973402-05-9)
- Dolutegravir Impurity 2 (CAS 1309560-49-3)
- Dolutegravir Impurity 4 (CAS 1357289-37-2)
- Dolutegravir Impurity 6 (CAS 2244161-72-4)
- Dolutegravir Impurity 44 (CAS 2518311-04-9)
- Dolutegravir Impurity 45 (CAS 2244245-33-6)
- Dolutegravir Impurity 49 (CAS CATO-C4X-162049)
Recommended Standards
- 4-Bromo-5-methoxy-2-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzenesulfonamide (CAS 898647-24-0)
- 3-Amino-N-(4-methyl-1,3-oxazol-2-yl)-6-(pyridin-4-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 626225-38-5)
- 3-(4,5-Dimethoxy-2-nitrophenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid (CAS 353-23-6)
- 2-((5-Cyano-4-(trifluoromethyl)-[2,4'-bipyridin]-6-yl)thio)-N-(4-methyloxazol-2-yl)acetamide (CAS 625378-11-2)
- Anastrozole EP Impurity G (CAS 120511-92-4)
- Nemonoxacin Impurity 65 (CAS CATO-C4X-312865)
- Fluorometholone Impurity B (CAS 83873-16-9)
- Methyl 2-(4-hydroxyphenethyl)-6-methoxybenzoate (CAS 65819-12-7)
- (3S)-3-ethyl-1-methyl-piperazine (CAS 1821830-26-5)
- N-(2-Bromoethyl)aniline hydrobromide (CAS 1005-66-9)
- Aspon (CAS 3244-90-4)
- 1-Carbamimidamido-N-(2,6-difluorophenyl)methanimidamide hydrochloride (CAS 242475-27-0)
- (3-Fluoro-5-methylphenyl)methanol (CAS 518070-20-7)
- Hexapeptide-9 (CAS 1228371-11-6)
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