Dolutegravir Impurity 2 CAS 1309560-49-3
| CAS No. | 1309560-49-3 |
| Molecular Formula | C20H19F2N3O5 |
| Molecular Weight | 419.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Dolutegravir Impurity 2 (CAS 1309560-49-3), a pharmacopoeial impurity reference standard (molecular formula C20H19F2N3O5, MW 419.38 g/mol) used for the identification and quantification of trace impurities in APIs.
Dolutegravir Impurity 2 (C20H19F2N3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H19F2N3O5 |
| Molecular Weight | 419.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir (CAS 1051375-16-6)
- Dolutegravir Impurity 1 (CAS 1357289-29-2)
- Dolutegravir Impurity 11 (CAS 1973402-05-9)
- Dolutegravir Impurity 4 (CAS 1357289-37-2)
- Dolutegravir Impurity 6 (CAS 2244161-72-4)
- Dolutegravir Impurity 44 (CAS 2518311-04-9)
- Dolutegravir Impurity 45 (CAS 2244245-33-6)
- Dolutegravir Impurity 49 (CAS CATO-C4X-162049)
Recommended Standards
- Cabotegravir Impurity 10 (CAS CATO-C4X-287610)
- 4-Bromo-5-methoxy-2-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzenesulfonamide (CAS 898647-24-0)
- Prosulfuron (CAS 94125-34-5)
- 3-Amino-N-(4-methyl-1,3-oxazol-2-yl)-6-(pyridin-4-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 626225-38-5)
- Palbociclib Impurity 158 (CAS 2639903-34-5)
- rac-Melphalan EP Impurity B (CAS 1259994-01-8)
- Lotilaner Impurity 26 (CAS 2758907-90-1)
- 2-[2-(1H-Imidazol-2-yl)ethyl]-1H-isoindole-1,3(2H)-dione (CAS 88883-77-6)
- 4-Chloro-n,n-diethylbutanamide (CAS 56794-28-6)
- 2-Chloro-n-propyl-n-[(propylcarbamoyl)methyl]acetamide (CAS 1178363-63-7)
- 2-(5Z)-5-Tetradecen-1-yl-cyclobutanone (CAS 173074-85-6)
- 3-((4-Chloro-1H-pyrazol-1-yl)methoxy)benzaldehyde (CAS 1006460-35-0)
- 5217-47-0 BXB40M6A7W 1,3-Diethyl-2-thiobarbituric acid Barbituric acid, 1,3-diethyl-2-thio- (8CI) 1,3-Diethyldihydro-2-thioxopyrimidine-4,6(1H,5H)-dione 4,6(1H,5H)-Pyrimidinedione, 1,3-diethyldihydro-2-thioxo- N,N'-Diethylthiobarbituric acid N,N'-Diethyl-2-thiobarbituric acid 1,3-Diethylthiobarbituric acid EINECS 226-010-7 NSC 158284 UNII-BXB40M6A7W (CAS 5217-47-0)
- Semaglutide-d5 (CAS CATO-C4X-2226153)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com