Dolutegravir Impurity 11 CAS 1973402-05-9
| CAS No. | 1973402-05-9 |
| Molecular Formula | C20H19F2N3O5 |
| Molecular Weight | 419.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Dolutegravir Impurity 11 (CAS 1973402-05-9, C20H19F2N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Dolutegravir Impurity 11 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 419.38 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Dolutegravir Impurity 11 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H19F2N3O5 |
| Molecular Weight | 419.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir (CAS 1051375-16-6)
- Dolutegravir Impurity 1 (CAS 1357289-29-2)
- Dolutegravir Impurity 2 (CAS 1309560-49-3)
- Dolutegravir Impurity 4 (CAS 1357289-37-2)
- Dolutegravir Impurity 6 (CAS 2244161-72-4)
- Dolutegravir Impurity 44 (CAS 2518311-04-9)
- Dolutegravir Impurity 45 (CAS 2244245-33-6)
- Dolutegravir Impurity 49 (CAS CATO-C4X-162049)
Recommended Standards
- 4-Bromo-5-methoxy-2-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzenesulfonamide (CAS 898647-24-0)
- 3-Amino-N-(4-methyl-1,3-oxazol-2-yl)-6-(pyridin-4-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 626225-38-5)
- Cabotegravir Impurity 10 (CAS CATO-C4X-287610)
- 3-(4,5-Dimethoxy-2-nitrophenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid (CAS 353-23-6)
- Norethindrone Impurity 5 (CAS 16392-60-2)
- Niraparib Impurity N9 (CAS 1203683-54-8)
- Trazodone Impurity 70 (CAS CATO-C4X-177270)
- 1-(5-Bromo-1H-benzo[d]imidazol-2-yl)-2-methylbutan-1-amine (CAS 1179187-38-2)
- Flumazenil Impurity 18 (CAS CATO-C4X-143218)
- 5-Fluoro-4-(trifluoromethyl)azepan-4-ol hydrochloride (CAS 1823245-41-5)
- N-(4-Acetamidophenyl)-2-((3-(4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 477330-70-4)
- 1-[(4-Chlorophenyl)sulfanyl]-2-{[(4-chlorophenyl)sulfanyl]methyl}benzene (CAS 337923-81-6)
- 4-bromo-1H-pyrrolo[2,3-b]pyridine-6-carbonitrile (CAS 1190310-18-9)
- Peptide Impurity 26 (CAS 1350456-66-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com