Dolutegravir Impurity 4 CAS 1357289-37-2
| CAS No. | 1357289-37-2 |
| Molecular Formula | C20H19F2N3O5 |
| Molecular Weight | 419.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Dolutegravir Impurity 4 (CAS 1357289-37-2), a pharmacopoeial impurity reference standard (molecular formula C20H19F2N3O5, MW 419.38 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Dolutegravir Impurity 4 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 419.38 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Dolutegravir Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H19F2N3O5 |
| Molecular Weight | 419.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir (CAS 1051375-16-6)
- Dolutegravir Impurity 1 (CAS 1357289-29-2)
- Dolutegravir Impurity 11 (CAS 1973402-05-9)
- Dolutegravir Impurity 2 (CAS 1309560-49-3)
- Dolutegravir Impurity 6 (CAS 2244161-72-4)
- Dolutegravir Impurity 44 (CAS 2518311-04-9)
- Dolutegravir Impurity 45 (CAS 2244245-33-6)
- Dolutegravir Impurity 49 (CAS CATO-C4X-162049)
Recommended Standards
- Cabotegravir Impurity 10 (CAS CATO-C4X-287610)
- Prosulfuron (CAS 94125-34-5)
- (3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one (CAS 1009817-63-3)
- 4-Bromo-5-methoxy-2-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzenesulfonamide (CAS 898647-24-0)
- Olanzapine Impurity 59 (CAS CATO-C4X-117859)
- Neratinib Impurity 2 (CAS 1144516-20-0)
- Dyclonine Impurity 21 (CAS 7182-38-9)
- 2-(3-Chloropropyl)-6,7-dimethoxyquinazoline (CAS 2006277-49-0)
- 5-Bromo-2-(2-(tert-butoxy)ethoxy)-3-methoxypyridine (CAS 1299607-50-3)
- N-(6-Formyl-4-iodopyridin-2-yl)acetamide (CAS 1393550-66-7)
- 2-methoxy-N-methylpyridin-3-amine (CAS 1334149-22-2)
- (E)-3-(6-(4-bromophenyl)imidazo[2,1-b]thiazol-5-yl)-1-(4-propylphenyl)prop-2-en-1-one (CAS 691887-88-4)
- 1-(4-Bromobenzyl)-1H-pyrazole (CAS 1159826-63-7)
- Semaglutide impurity 74 (CAS CATO-C4X-222674)
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