Dolutegravir Impurity 6 CAS 2244161-72-4
| CAS No. | 2244161-72-4 |
| Molecular Formula | C20H19F2N3O5 |
| Molecular Weight | 419.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Dolutegravir Impurity 6 (C20H19F2N3O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Dolutegravir Impurity 6 (CAS 2244161-72-4), a pharmacopoeial impurity reference standard (molecular formula C20H19F2N3O5, MW 419.38 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Dolutegravir Impurity 6 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H19F2N3O5 |
| Molecular Weight | 419.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir (CAS 1051375-16-6)
- Dolutegravir Impurity 1 (CAS 1357289-29-2)
- Dolutegravir Impurity 11 (CAS 1973402-05-9)
- Dolutegravir Impurity 2 (CAS 1309560-49-3)
- Dolutegravir Impurity 4 (CAS 1357289-37-2)
- Dolutegravir Impurity 44 (CAS 2518311-04-9)
- Dolutegravir Impurity 45 (CAS 2244245-33-6)
- Dolutegravir Impurity 49 (CAS CATO-C4X-162049)
Recommended Standards
- Cabotegravir Impurity 10 (CAS CATO-C4X-287610)
- Prosulfuron (CAS 94125-34-5)
- (3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one (CAS 1009817-63-3)
- 2-[2-[[(Benzhydryloxy)carbonyl]amino]-6-oxo-1H-purin-9(6H)-yl]acetic Acid (CAS 169287-79-0)
- Cefotaxime Impurity 68 (CAS CATO-C4X-120168)
- Abrocitinib Impurity 50 (CAS CATO-C4X-288450)
- Dopamine Impurity 103 (CAS CATO-C4X-1908103)
- 2-Methyl-4-(piperidin-4-yl)phenol (CAS 1260875-76-0)
- (R)-3-((tert-Butoxycarbonyl)amino)-3-(3,4-dimethoxyphenyl)propanoic acid (CAS 500788-93-2)
- 3-benzyl-8-azabicyclo[3.2.1]octane (CAS 338733-58-7)
- 3-(Pyridin-4-yl)-5H-indeno[1,2-c]pyridazin-5-one (CAS 303145-58-6)
- 3-Bromo-2-fluoro-6-(trifluoromethyl)phenylboronic acid (CAS 1451392-89-4)
- 6,8-Dimethyl-4-quinolinamine (CAS 929339-38-8)
- Semaglutide impurity 36 (CAS CATO-C4X-222636)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com